Lipoprotein removal by soluble enzymes

Details Lipoprotein removal by soluble enzymes Lipoprotein removal by soluble enzymes

1990-08-14

1993-01-12

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

424520, 424 946, 424542, 514267, 514182, A61K 3748, A61K 3754

Patent

active

051788640

ABSTRACT:
A therapeutically effective amount of soluble phospholipase A.sub.2 is administered into a subject for lowering the low density lipoproteins ("LDL") in the blood. Phospholipase A.sub.2 modifies the plasma LDL by hydrolyzing the phospholipids present in LDL. As a result, the modified LDL is rapidly removed from the bloodstream by the catabolic processes.

REFERENCES:
patent: 4079125 (1978-03-01), Sipos
patent: 4311788 (1982-01-01), Heuck
patent: 4748161 (1988-05-01), Kimura et al.
patent: 4775483 (1988-10-01), Mookerjea et al.
patent: 4822608 (1989-04-01), Benton et al.
patent: 4927629 (1990-05-01), Bing
Heinrikson, et al., J. Biol. Chem. 252, pp. 4913-4921 (1977), USA.
Kramer, et al., J. Biol. Chem. 264, pp. 5768-5775 (1989), USA.
Aggerbeck, et al., J. Biol. Chem. 251, pp. 3823-3830 (1976), USA.
Vadas et al., Lab. Invest., 55, pp. 391-404 (1986), USA.
Mullon et al., Presentation at AIChE annual meeting (Nov. 1989) USA.
Litwin et al., J. of Allergy Clinical Immunology, vol. 75, 1 part 2, 1985, p. 151.
Marmer et al., Chem. Abstracts vol. 90:995809 (1979).

Affiliated with

Also associated with

Rating

Lipoprotein removal by soluble enzymes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Lipoprotein removal by soluble enzymes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lipoprotein removal by soluble enzymes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1218309