Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Reexamination Certificate
2005-03-22
2005-03-22
Witz, Jean C. (Department: 1651)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
C424S522000, C424S725000
Reexamination Certificate
active
06869603
ABSTRACT:
The present invention is directed to compositions which include the enzyme lipoprotein lipase. These compositions may be applied topically to the skin of a person to prevent dryness or treat inflammation. In addition, the invention is directed to the use of fibrates to enhance the activity of lipoprotein lipase. The fibrates may be used orally to treat inflammation or enhance metabolic energy production.
REFERENCES:
patent: 4701322 (1987-10-01), Dixon et al.
patent: 4707354 (1987-11-01), Garlen et al.
patent: 4760095 (1988-07-01), Djerassi et al.
patent: 4784849 (1988-11-01), Tutsky
patent: 5219558 (1993-06-01), Woodin, Jr. et al.
patent: 5256404 (1993-10-01), Martino et al.
patent: 5310556 (1994-05-01), Ziegler
patent: 5463092 (1995-10-01), Hostetler et al.
patent: 5494657 (1996-02-01), Swenson
patent: 5665379 (1997-09-01), Hërslof et al.
patent: 5981586 (1999-11-01), Pershadsingh
patent: 6028109 (2000-02-01), Willson
patent: 6060515 (2000-05-01), Elias et al.
patent: 6267985 (2001-07-01), Chen et al.
Bardot, et al., “PPAR-RXR Heterodimer Activates a Peroxisome Proliferator Response Element Upstream of the Bifunctional Enzyme Gene,”Biochem. Biophys. Res. Comm. 192:37-45 (1993).
Göttlicher, et al., “Fatty Acids Activate a Chimera of the Clofibric Acid-Activated Receptor and the Glucocorticoid Receptor,”Proc. Natl. Acad. Sci. USA 89:4653-4657 (1992).
Issemann, et al., “Activation of a Member of the Steroid Hormone Receptor Superfamily by Peroxisome Proliferators,”Nature 347:645-650 (1990).
Marcus, et al., “Diverse Peroxisome Proliferator-Activated Receptors Bind to the Peroxisome Proliferator-Responsive Elements of the Rat Hydratase/Dehydrogenase and Fatty acyl-CoA Oxidase Genes but Differentially Induce Expression,”Proc. Natl. Acad. Sci. USA 90:5723-5727 (1993).
Muerhoff, et al., “The Peroxisome Proliferator-Activated Receptor Mediates the Induction ofCYP4A6, a Cytochrome P450 Fatty Acid ω-Hydroxylase, by Clofibric Acid,”J. Bio. Chem. 267:19051-19053 (1992).
Reddy, et al., “Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans,”Crit. Rev. Toxicol. 12:1-58 (1983).
Tugwood, et al., “The Mouse Peroxisome Proliferator Activated Receptor Recognizes a Response Element in the 5′ Flanking Sequence of the Rat Acyl CoA Oxidase Gene,”EMBO J. 11:433-439 (1992).
Plutzky Jorge
Ziouzenkova Ouliana
Fitch Even Tabin & Flannery
Sanzo Michael A.
The Brigham and Women's Hospital, Inc.
Witz Jean C.
LandOfFree
Lipoprotein lipase and lipoprotein lipase activators in the... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Lipoprotein lipase and lipoprotein lipase activators in the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lipoprotein lipase and lipoprotein lipase activators in the... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3438370