Lipopolysaccharide and process for preparation thereof

Details Lipopolysaccharide and process for preparation thereof Lipopolysaccharide and process for preparation thereof

1986-07-28

1988-05-24

Wiseman, Thomas G.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

435101, 435134, 536 11, A61K 3902, C12P 1904, C12P 764, C07H 1100

Patent

active

047465115

ABSTRACT:
A lipopolysaccharide characterized by a polysaccharide portion composed of D-arabinose and D-mannose in a 1:3/4 ration and 37 to 47% of a fatty acid portion having 14-19 carbon atoms bonded to the polysaccharide through an ester linkage. This lipopolysaccharide has physiological activities such as antitumor activity, immunizing activity, cell juvenescent activity, phagocyte activating activity, and infection preventing activity.
This lipopolysaccharide is prepared by culturing a Mycobacterium or a Propionibacterium and extracting the lipopolysaccharide from the culture with a non-ionic surface active agent and purifying the extract with a molecular sieve.

REFERENCES:
patent: 4315919 (1982-02-01), Shanbrom
patent: 4329452 (1982-05-01), Maruyama
patent: 4479935 (1984-10-01), Metianu et al.
Gray et al. Methods Enzymol 35: 90-95, 1975.

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