Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-08-26
1989-06-06
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514326, 546277, 546210, C07D41304, A61K 3144
Patent
active
048372412
ABSTRACT:
New piperidine compounds having the formula ##STR1## wherein at least one of R.sup.3, R.sup.4, and R.sup.5 are ##STR2## and the other independently are H, C.sub.1-6 -alkyl, wherein R' is H, C.sub.1-8 -alkyl, phenyl, thienyl, cyclopropyl, or C.sub.1-3 -alkoxymethyl; and R.sup.1 and R.sup.6 independently are H or C.sub.1-6 -alkyl, and wherein ##STR3## and salts thereof with pharmaceutically-acceptable acids. The new compounds are useful in improving the cognitive functions of the forebrain and hippocampus of mammals, and are therefore useful in the treatment of Alzheimer's disease.
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Iverson, L. L.: The Cholinergic Hypothesis of Dementia. Trends in Pharmacological Sciences, pp. 44-45 (1986).
Palacios, J. M. et al.: Mapping of Subtypes of Muscarinic Receptors in the Human Brain with Receptor Autoradiographic Techniques. Trends in Pharmacological Sciences, pp. 56-60 (1986).
Smith, C. J. et al.: Muscarinic Cholinergic Receptor Subtypes in Hippocampus in Human Cognitive Disorders. J. Neurochem. vol. 50 (3), pp. 847-855 (1988).
The Hydrophobic Fragmental Constant by Rekker, vol. 1 of Pharmaco Chemistry Library by Elsevier Scientific Publishing Company (1977), pp. 78, 48, 119, 113-117.
Jensen Leif H.
Kindtler Jens W.
Sauerberg Per
Watjen Frank
A/S Ferrosan
Fan Jane T.
Hueschen Gordon W.
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