Lipophilic quenching of viral inactivating agents

Details Lipophilic quenching of viral inactivating agents Lipophilic quenching of viral inactivating agents

1999-01-25

2000-11-21

Yucel, Remy

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435236, 514 44, 536 231, 536 245, C12Q 168, C12N 704, C07H 2104, A61K 4800

Patent

active

061501093

ABSTRACT:
Methods and compositions for the inactivation and removal of contaminants of a biological composition are disclosed. The methods include the steps of: (a) contacting the biological composition with an inactivating agent including an aziridino moiety, such as ethyleneimine, an oligomer of ethyleneimine, or a haloderivative salt of either ethyleneimine or an oligomer of ethyleneimine, where a portion of the agent reacts with and inactivates the contaminant, and a portion of the agent remains unreacted; (b) contacting the product of step (a) with a lipophilic quenching agent including at least one quenching moiety attached to a lipophilic moiety, under conditions and for a time sufficient to allow the unreacted agent to bond covalently to the quenching moiety; and (c) separating the lipophilic quenching agent and the quenched inactivating agent from the biological composition.

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Bahnemann, Vaccine vol. 8, pp. 299-304, Aug. 1990.
Budowsky et al, Vaccine Res. vol. 5 #1, p29-39, Nov. 1996.

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