Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1995-06-07
1999-12-21
Smith, Lynette R. F.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514552, 514558, 514560, A01N 3706, A01N 3702, A61K 3122, A61K 3123
Patent
active
060050047
ABSTRACT:
The present invention describes site-specific biomolecular complexes comprising a therapeutic, prophylactic and diagnostic agent, called also biologically active molecule and an omega-3 fatty acid and derivatives thereof. The complexes are further covalently bonded with cationic carriers and permeabilizer peptides for delivery across the blood-brain barrier and with targeting moieties for uptake by target brain cells. Said complexes are particularly useful for delivery of a biologically active agent to the glial tissue of the brain as well as to the cortical, cholinergic and adrenergic neurons. The preferred therapeutic complexes or conjugates comprise an omega-3 fatty acid such as alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid and derivatives thereof.
REFERENCES:
patent: 4861597 (1989-08-01), Kida et al.
patent: 5210076 (1993-05-01), Berliner et al.
patent: 5225212 (1993-07-01), Martin et al.
patent: 5433946 (1995-07-01), Allen, Jr. et al.
patent: 5434183 (1995-07-01), Larsson-backstrom
patent: 5476660 (1995-12-01), Somasindaran et al.
patent: 5604198 (1997-02-01), Poduslo et al.
Frenkel. "Gaucher disease: a heterogenous clinical complex for which effective enzyme replacement has come of age". American Journal of the Medical Sciences. vol.305, No.5, pp. 331-344, May 1993.
Katz Robert
Tomoaia-Cotisel Maria
Angres Isaac
Lee Datquan
Molecular / Structural Biotechnologies, Inc.
Smith Lynette R. F.
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