Lipophilic polyamines providing enhanced intracellular...

Details Lipophilic polyamines providing enhanced intracellular... Lipophilic polyamines providing enhanced intracellular...

2011-03-22

2011-03-22

Schultz, James (Doug) (Department: 1633)

Chemistry: molecular biology and microbiology

Vector, per se

C435S455000, C424S093210, C514S04400A

Reexamination Certificate

active

07910363

ABSTRACT:
Polyamine cationic lipids have been synthesized that have the ability to be transported into cells having an active polyamine transport system. Accordingly, these lipids may be conjugated with various agents and, thereby, act as vectors for transporting the agent into the cell aided by the cell's own polyamine transport system. A method of delivering an agent into a cell includes associating the agent with a polyamine cationic lipid selected from compounds 25, 26, 27, 28, their pharmaceutically acceptable salts and combinations thereof and contacting the cell therewith.

REFERENCES:
Gardener et al. J Med Chem 50:308-318; Jan. 2005.

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