Lipophilic polyamine esters for the site specific delivery of ni

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

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514547, 514551, 514611, 514645, 552547, 560169, 564113, 564297, A61K 3113, A61K 31195, C07C22926, C07C24342

Patent

active

061470686

ABSTRACT:
A pharmaceutical composition of matter for delivering nitric oxide. The composition is an amine that was reacted with nitric oxide. The composition of matter is lipophilic and insoluble and therefore delivers nitric oxide to the specific area of the body where it is introduced. Also, a method of synthesizing an amine and reacting it with nitric oxide to form the pharmaceutical composition of matter. Finally, a method of using the pharmaceutical composition of matter to deliver nitric oxide to the body.

REFERENCES:
patent: 5039705 (1991-08-01), Keefer et al.
patent: 5049389 (1991-09-01), Radhakrishnan
patent: 5155137 (1992-10-01), Keefer et al.
patent: 5185376 (1993-02-01), Diodati et al.
patent: 5208233 (1993-05-01), Keefer et al.
patent: 5266480 (1993-11-01), Naughton et al.
patent: 5358715 (1994-10-01), Wong et al.
patent: 5366997 (1994-11-01), Keefer et al.
patent: 5371089 (1994-12-01), Rattan
patent: 5385937 (1995-01-01), Stamler et al.
patent: 5389675 (1995-02-01), Christodoulou et al.
patent: 5443950 (1995-08-01), Naughton et al.
patent: 5455335 (1995-10-01), Kahne et al.
patent: 5525357 (1996-06-01), Keefer et al.
patent: 5650442 (1997-07-01), Mitchell et al.
patent: 5650447 (1997-07-01), Keefer et al.
"The Reaction of Nitrogen (II) Oxide with Diethylamine" by Drago and Paulik, Contribution from the W.A. Noyes Laboratory, University of Illinois, pp. 96-98, 1959.
"Polycondensation of .omega.-Aminoalkylamino Acid Esters" by Asahara, Basic Research Laboratory, Toray Industries, Inc., Japan, pp. 211-219, 1970.
"Thermal Bulk Polymerization of Cholesteryl Acrylate" by Visser et al., Twente University of Technology, Netherlands, pp. 1893-1894, 1971.
"Synthesis of Putreanine and of Spermic Acid" by Tabor and Tabor, Methods in Enzymology, vol. 94, pp. 418-422, 1983.
"Complexes of NO with Nucleophiles as Agents for the Controlled Biological Release of Nitric Oxide. Vasorelaxant Effects" by Maragos et al., J. Med. Chem., vol. 34, pp. 3242-3247, 1991.
"The Molecule of the Year" by Koshland, Jr., Science, vol. 258, pp. 1861-1865, 1992.
Morrison et al., Organic Chemistry, Fifth Edition, Allyn and Bacon, Inc., New York, p. 865, 1987.
"New Nitric Oxide-Releasing Zwitterions Derived from Polyamines" by Hrabie and Klose, J. Org. Chem., vol. 5c, pp. 1472-1476, 1993.
"The Surprising Life of Nitric Oxide" by Feldman et al., C&EN, Special Report, pp. 26-38, 1993.
"Toward the generation of No in Biological Systems. Theoretical Studies of the N.sub.2 O.sub.2 Grouping" by Taylor et al., J. Org. Chem., vol. 60, pp. 435-444, 1995.
"Nitric Oxide and Asthma" by Barnes, National Heart and Lung Institute, London, pp. 698-702.
"Characterization and Nitric Oxide Release Studies of Lipophilic 1-Substituted Diazen-1jum-1,2-diolates" by Roselle and Smith, Journal of Controlled Release, vol. 51, pp. 131-142, 1998.
"Synthesis of Lipophilic 1-Substituted Diazen-1ium-1,2-diolates" by Roselle and Smith, Chem. Pharm. Bull., 45(4), pp. 747-749, 1997.
"Secondary Amine/Nitric Oxide Complex Ions, R.sub.2 N[N(O)NO] O-Functionalization Chemistry" by Saavedra et al., J. Org. Chem., vol. 57, pp. 6134-6138, 1992.

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