Lipophilic drug derivatives for use in liposomes

Details Lipophilic drug derivatives for use in liposomes Lipophilic drug derivatives for use in liposomes

1994-05-19

1996-07-09

Kunz, Gary L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 2, 514 34, 514449, 514463, 424 121, 424450, 536 41, 536 64, 536 172, 536 181, 549432, 549510, A61K 3170, A61K 31715, A61K 9127

Patent

active

055344992

ABSTRACT:
The present invention provides novel lipophilic drug derivatives which are capable of being formulated in liposomes or micelles. These drug derivatives are known therapeutic agents which are covalently attached to a fatty acid chain of a phospholipid, glyceride, ceramide or 1,2-diacyloxypropane-3-amine. The linkage between the therapeutic agent and the lipid is one which can be cleaved in vivo, allowing the therapeutic agent to be separated from the micellar or liposomal formulation.

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