Lipophilic cyanine dyes with enchanced aqueous solubilty

Details Lipophilic cyanine dyes with enchanced aqueous solubilty Lipophilic cyanine dyes with enchanced aqueous solubilty

1996-08-14

1999-12-21

Richter, Johann

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Diagnostic or test agent produces in vivo fluorescence

424 103, 436 63, 436172, 436 91, 436 92, 436 93, 436 96, 548152, 548156, 548159, 548217, 548219, 548469, 548491, 548494, 548503, 548510, 548518, A61K 4900, G01N 3348, C07D20904, C07D40306

Patent

active

060045361

ABSTRACT:
The present invention relates to a family of cyanine dyes possessing lipophilic alkyl chains and either one or more reactive functional groups, bromo or chloro, or phenyl, sulfophenyl or polysulfophenyl substituents or combinations thereof. The dyes of the invention are useful for staining membranes in cells or isolated from cells, and are well-retained therein. Additionally, the reactive dyes of the invention are useful for preparing dye-conjugates, thereby conferring the membrane staining ability of the subject dye onto the resulting dye-conjugate.

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