Lipophilic contrast agents for use in hepatocyte-selective oil-i

Details Lipophilic contrast agents for use in hepatocyte-selective oil-i Lipophilic contrast agents for use in hepatocyte-selective oil-i

1995-06-07

1997-08-05

Carr, Deborah D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

554 51, 554 55, 554 56, 554 61, 554 62, 554 63, 554 67, 554103, 554104, 554107, 554121, 554123, 554225, 554226, 554220, 554218, 554213, 560 8, 560 19, 560 37, 560 38, 560 47, 560103, 560105, 560110, G07C23300

Patent

active

056544529

ABSTRACT:
Aromatic acid-derived lipophilic polyhalogenated compounds are provided for use as contrast agents in diagnostic imaging or as therapeutic agents. These compounds are particularly useful when incorporated into an oil-in-water emulsion for tissue-specific delivery to the liver. For hepatocyte-selective delivery, the emulsion is chylomicron remnant-like by being in a size range of 50 to 200 nm and having a composition simulating naturally-occuring chylomicron remnants.

REFERENCES:
patent: 4873075 (1989-10-01), Caunsell et al.
patent: 5401483 (1995-03-01), Lohrmann et al.

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