Lipophilic contrast agents for diagnostic image analysis

Details Lipophilic contrast agents for diagnostic image analysis Lipophilic contrast agents for diagnostic image analysis

1994-08-18

1995-10-24

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 942, 534 16, 556 50, 556 63, 556107, 556117, 556134, 556148, 436173, 436806, 514492, 514502, 514558, 514563, 514836, A61B 5055, A61K 4904

Patent

active

054607990

ABSTRACT:
The present invention relates to contrast enhancing agents, conjugates thereof, pharmaceutical compositions thereof, and methods for diagnostic analysis, particularly NMR image analysis using these agents. The contrast enhancing agents are chelates of paramagnetic, ferromagnetic or diamagnetic metal ion(s) complexed with new lipophilic complexing acids related to polyaminopolycarboxylic acids.

REFERENCES:
patent: 3429915 (1969-02-01), Bersworth
patent: 4647447 (1987-03-01), Gries et al.
patent: 4687658 (1987-08-01), Quay
patent: 4687659 (1987-08-01), Quay
patent: 4804529 (1989-02-01), Bardy et al.
patent: 4826673 (1989-05-01), Dean et al.
patent: 5154914 (1992-10-01), Elgavish et al.
patent: 5242681 (1993-09-01), Elgavish et al.
Cupkova, V., Chem. Abstracts, CA112(1): 4197Y (1990).
Devinsky, Chem. Abstracts, CA102(26): 226400s (1985).
Yaroshenko, G. F. et al., "Synthesis of aminopolycarboxylic acid esters", Chem. Abstracts, vol. 80, 1974:478, Abstract No. 133388f (1974).
Kabaika, G. W. et al., "Gadolinium-labeled liposomes containing paramagnetic amphipathic agents: targeted MRI contrast agents for the liver", Chem. Abstracts, 8:Radiation, vol. 110:283 (1989).
Guilmette, R. A. et al., "Synthesis and therapeutic testing of mono- and dialkyl esters of pentetic (diethylenetriaminepentaacetic) acid for decorporation of polymeric plutonium", Chem. Abstract 90:567, Abstract No. 203405c (1979).
Schaefer, P., "Diester-amine adducts as fabric softeners", Chem. Abstracts 81: Abstract No. 51056c (1974).
Tilcock, "Liposomal Gd-DTPA: Preparation and Characterization of Relaxivity", Radiology, vol. 171, pp. 77-80 (1989).
Karesh, S. M. et al., "Biological Distribution of Chemical Analogs of Fatty Acids and Long Chain Hydrocarbons Containing a Strong Chelating Agent", J. Parm. Sci., vol. 66, pp. 225-228 (1977).
Weinmann, H. J. et al., "Characteristics of Gadolinium-DTPA Complex: A Potential NMR Contrast Agent", Amer. J. Radiol. vol. 142: pp. 619-624 (p. 623) (1984).
Brown, M. A., "Effects of the Operating Magnetic Field on Potential NMR Contrast Agents", Resonance Imaging, vol. 3, pp. 3-9 (p. 4) (1984).
Brown, M. A. et al., "Transition metal-chelate complexes as relaxation modifiers in nuclear magnetic resonance", Med. Phys. vol. 11, pp. 67-72 (p. 70) (1984).
Gadian, D. G. et al. "Gadolinium-DTPA as a Contrast Agent in MR Imaging Theoretical Projections and Practical Observations", J. Comp. Assist. Tomogr. vol. 9, pp. 242-251 (p. 244) (1985).

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