Lipophilic contrast agents for diagnostic image analysis

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure

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424 9, 436173, 1286534, 514492, 514502, 514550, 514836, 534 16, 556 44, 556 50, 556 63, 556107, 556117, 556134, 556148, G01N 2408, A61K 4904, A61K 3128, A61K 31295

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052426815

ABSTRACT:
The present invention relates to contrast enhancing agents, conjugates thereof, pharmaceutical compositions thereof, and methods for diagnostic analysis, particularly NMR image analysis using these agents. The contrast enhancing agents are chelates of paramagnetic, ferromagnetic or diamagnetic metal ion(s) complexed with new lipophilic complexing acids related to polyaminopolycarboxylic acids.

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Tilcock, "Liposomal Gd-DTPA: Preparation and Characterization of Relaxivity," (1989) Radiology 171: 77-80.

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