Lipophila derivatives of muramylpeptides having properties of ac

Details Lipophila derivatives of muramylpeptides having properties of ac Lipophila derivatives of muramylpeptides having properties of ac

1994-10-25

1997-12-30

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530322, 536 53, A61K 3814, A61K 3816, C07K 900

Patent

active

RE0357065

ABSTRACT:
The invention relates to muramyleptide derivatives resulting essentially from the conjugation or the coupling, as the case may require, through an arm, between a muramylpeptide and a group containing two atoms contiguous with one another to each of which is attached a lipophile chain comprising from 8 to 100 carbon atoms, preferably from 14 to 24 carbon atoms. The derivatives according to the invention are endowed with remarkable stimulating properties with respect to the activation of macrophages, of which they amplify the tumoricidal properties.

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