Lipopeptide derivatives, a process for their preparation and the

Details Lipopeptide derivatives, a process for their preparation and the Lipopeptide derivatives, a process for their preparation and the

1995-03-28

1997-05-13

Cain, Edward J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 11, 530317, A61K 3808

Patent

active

056292880

ABSTRACT:
Lipopeptide derivatives of the formula I ##STR1## with R.sup.1 equal to OH or NH.sub.2 and R.sup.2 a C.sub.8 -C.sub.22 -acyl radical, pharmaceutical products which are effective for bacterial infections and contain such lipopeptide derivatives, process for preparing the lipopeptide derivatives and the pharmaceutical products, and the use of the lipopeptide derivatives for controlling bacterial infections are described.

REFERENCES:
Debono et al., "Enzymatic and Chemical Modifications of Lipopeptide Antibiotic A21978C: The Synthesis and Evaluation of Daptomycin (LY146032)", Journal of Antibiotics, 41(8):1093-1105 (1988).
Allen et al., "Biosynthesis of Modified Peptidoglycan Precursors by Vancomycin-resistant Enterococcus Faecium", FEMS Microbiology Letters, 98:109-116 (1992).
Altmann et al., "Die Chemische Synthese von Peptiden und Proteinen", Chemie in Unsere Zeit, 27(6):274-286 (1993).
Shoji et al., "Studies on Tsushimycin, II The Structures of Constituent Fatty Acids," The Journal of Antibiotics, vol. XXII, No. 10, 1969, pp. 473-479.
Strong et al., "Studies on the Amino Acid Sequence of Amphomycin," Antimicrobial Agents and Chemotherapy, 1970, pp. 42-45.

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