Lipopeptide derivatives

Details Lipopeptide derivatives Lipopeptide derivatives

1991-03-15

1994-11-29

Hill, Jr., Robert J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, 530317, A61K 3702, C07K 706, C07K 512

Patent

active

053690931

ABSTRACT:
The present invention is directed to water-soluble derivatives of antibiotic lipopeptides having the formula. ##STR1## wherein R is H or OH and R' is a phosphono, sulfo or acyl radical possessing a charged group at neutral pH.
The derivatives are esters but having a charged group, have good solubility properties in aqueous medium, rendering them more useful as therapeutic agents.

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Traber et al., Helv. Chim. Acta 62, 4, 1252-67 (1979).
Pache, W. et al., 13th International Congress Chemotherapy (1983), PS 4.8/3, Part 115, Abstract No. 10; also references in Ann. Reports in Med. Chem. 19, Sec. III, 130-131.

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