Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1984-05-31
1985-10-29
Hoke, Veronica P.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C07D24100
Patent
active
045501092
ABSTRACT:
The present invention provides lipoidal biopterin and tetrahydrobiopterin compounds of the general structure: ##STR1## wherein --R is absent when ring B has two double bonds,
REFERENCES:
patent: 4371514 (1983-02-01), Nagatsu et al.
Schaub, J. et al., (Archives of Disease in Childhood, 1978, 53, 674-683).
Helvetica Chimica Acta--vol. 62, Fasc. 8(1979)--Nr. 264 264, Uber Pterinchemie 72, Mitteilung.sup.1) Trennung der Diastereomeren (6R)-und (6S)-5,6,7,8-Tetrahydro-1-Biopterin von Hans-Jurg Furrer, et al.
Matalon et al. (Annals of Clinical and Laboratory Sc.) vol. 12, No. 5, 411-414.
Niederwieser et al. (Eur. J. Pediatr., 138, 110-112) Original Investigations Atypical Phenylketonuria with Defective Biopterin Metabolism, Monotherapy with Tetrahydrobiopterin or Sepiapterin, Screening and Study of Biosynthesis in Man.
Kaufman et al. (Pediatrics, vol. 70, No. 3, Sep. 1982 376-380) Use of Tetrahydropterins in the Treatment of Hyperphenylalaninemia due to Defective Synthesis of Tetrahydrobiopterin.
Curtius et al. (J. Neural Transmission, vol. 55, 301-308) Short Communications Tetrahydrobiopterin: Efficacy in Endogenous Depression and Parkinson's Disease.
Niederwieser et al. (Eur. J. Pediatr.(1982) 138, Hyperphenylalaninemia with Neopterin Deficiency--A New Enzyme Defect Presumably of GTP Cyclohydrolase.
Leeming, et al. (Biochemical Medicine 30, 328-332(1983)) Intestinal Absorption of Tetrahydrobiopterin and Biopterin in man.
Bech, et al. (Acta Paediatr Scand. 72:449-454, 1983 Diagnostic and Therapeutic Aspects of Dihydrobiopterin Deficiency.
Curtius, et al. (Lancet, Mar. 19, 1983) 657-658 Serological and Biochemical Data.
Kaufman, et al. (Annals of Neurology vol. 14, No. 3, Sep. 1983 308-315) Tetrahydropterin Therapy for Hyperphenylalaninemia caused by Defective Synthesis of Tetrahydrobiopterin.
Kuster et al. (J. Chromatog., 278, 245-254) Gas Chromatog. Mass Spectrometry of Trimethylsilyl Pteridines.
Chemical Abstract 99:175478H 1',2'-Diacyl-(6R,S)-5,6,7,8-Tetrahydro-1-Biopterin (1983).
Niederwieser et al. (Eur. J. Pediatr., 141, 208-214) GTP Cyclohydrolase I Deficiency, a new Enzyme Defect causing Hyperphenylalaninemia with Neopterin, Biopterin, Dopamine, and Serotonin Deficiencies and Muscular Hypotonia.
Science vol. 219, Jan. 7, 1983 Effects of Tryosine Administration on Serum Biopterin in Normal Controls and Patients with Parkinson's Disease.
Folkers Karl
Laesecke Klaus P.
Hoke Veronica P.
The Board of Regents The University of Texas System
LandOfFree
Lipoidal biopterin compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Lipoidal biopterin compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lipoidal biopterin compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-728710