Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1991-11-25
1994-05-24
Hill, Jr., Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530395, C07K 1500
Patent
active
053149920
ABSTRACT:
A new cellular protein produced by activated monocytes
eutrophils and mononuclear cells, and involved in the binding of lipocortin-1 has been discovered. Methods for isolating and purifying this substantially pure lipocortin-1 receptor protein are disclosed herein as well as techniques for cloning and expressing the protein and related materials. Techniques for raising monoclonal antibodies to this protein, and diagnostic and therapeutic uses for this protein are also disclosed.
REFERENCES:
patent: 4874743 (1989-10-01), Wallner et al.
patent: 4879224 (1989-11-01), Wallner et al.
patent: 4917826 (1990-04-01), Johnson et al.
patent: 4937324 (1990-06-01), Fujikawa et al.
patent: 4950646 (1990-08-01), Wallner et al.
patent: 5051364 (1991-09-01), Isacke et al.
Jacobs, et al., "Isolation and Characterization of Genomic and cDNA Clones of Human erythropoietin", Nature, vol. 313, Feb. 28, 1985, pp. 806-810.
Ando et al., "Calcium-induced Intracellular Cross-linking of Lipocortin I by Tissue Transglutaminase in A431 Cells", The Journal of Biological Chemistry, 1991, vol. 266, No. 2, pp. 1101-1108.
Ando et al., "Enhancement of Calcium Sensitivity of Lipocortin I in Phospholipid Binding Induced by Limited Proteolysis and Phosphorylation at the Amino Terminus as Analyzed by Phospholipid Affinity Column Chromatography", The Journal of Biological Chemistry, 1989, vol. 264, No. 12, pp. 6948-6955.
Andree et al., "Binding of Vascular Anticoagulant (VAC) to Planar Phospholipid Bilayers", The Journal of Biological Chemistry, 1990, vol. 265, No. 9, pp. 4923-4928.
Blackwood et al., "Characterization of Ca.sup.2+ -dependent Phospholipid Binding, vesicle Aggregation and Membrane Fusion by annexins", Biochem. J., 1990, vol. 266, pp. 195-200.
Meers "Location of Tryptophans in Membrane-Bound Annexins", Biochemistry, 1990, vol. 29, No. 13, pp. 3325-3330.
Tait et al., "Phospholipid Binding Properties of Human Placental Anticoagulant Protein-I, a Member of the Lipocortin Family", The Journal of Biological Chemistry, 1989, vol. 264, No. 14, pp. 7944-7949.
Thomas et al., 1990, Methods in Enzymology, 182, 499-520, "Purification of Membrane Proteins".
Goulding et al., Characteristics of Lipocortin-I Binding . . . , 1990, Biochem. Soc. Trans., 18(6), 1237-8.
Hirata et al., (1980), Biochem., 77:1553-2536.
Wallner et al., (1986), Nature, 320:77-81.
Flower, (1988), Br. J. Pharmacol., 94:987-1015.
Fradin et al., (1988), Biochim. Biophys. Acta, 963:248-257.
Glenney et al., (1988), Biochem., 27:2069-2076.
Pepinsky et al., (1988), J. Biol. Chem., 263:10799-10811.
Cirino et al., (1989), Proc. Natl. Acad. Sci. USA, 86:3428-3432.
Maridonneau-Parini et al., (1989), J. Clin. Invest., 83:1936-1940.
Rothhut et al., (1989), Biochem. J., 263:929-935.
Browing et al., (1990), in Cytokines and Lipocortins-I in Inflammation and Differentiation, (Melli et al., eds.), Wiley-Liss, New York, pp. 27-45.
Goulding et al., (1990), Lancet, 335:1416-1418.
Goulding Nicolas J.
Guyre Paul M.
Hill Jr. Robert J.
Teng Sally
Trustees of Dartmouth College
LandOfFree
Lipocortin-1 receptor protein and its uses does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Lipocortin-1 receptor protein and its uses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lipocortin-1 receptor protein and its uses will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1973658