Chemistry: molecular biology and microbiology – Vector – per se
Patent
1995-06-23
1999-06-01
Crouch, Deborah
Chemistry: molecular biology and microbiology
Vector, per se
4351721, 4351723, 435 691, 435325, 514 44, 424 9321, C12N 1563
Patent
active
059087773
ABSTRACT:
A simple, rapid method for creating a lipidic vector for delivery of a therapeutic molecule entails bringing the molecule into contact with a polycation, thereby forming a complex, and then mixing the complex with an anionic lipidic preparation. Tissue-specific targeting peptides, fusogenic peptides and nucleus-targeting peptides also can be added to the lipid preparation. The result is a stable lipidic vector of reduced immunogenicity and cytotoxicity. The vector also displays enhanced transfection activity.
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Huang Leaf
Lee Robert J.
Crouch Deborah
Schmuck Jill D.
University of Pittsburgh
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