Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1995-04-11
1997-09-09
Eisenschenk, Frank C.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
4284022, 514 44, 514 8, A61K 9127, A61K 938
Patent
active
056653808
ABSTRACT:
A method for transmitting a biologically active material to a cell is provided. The method involves encapsulating the material to be transmitted in a paucilamellar non-phospholipid carrier vesicle which does not lyse cells upon fusion with cells, delivering the carrier vesicle to a location proximate to the cell, allowing the non-phospholipid bilayer of the carrier vesicle to fuse with the membrane of the cell and allowing the encapsulated material to diffuse into the cell. The method can be used to transmit a variety of biologically active materials to cells either in vitro or in vivo. The method provides a means for transmitting a biologically active material directly to the cytoplasm of a cell. Upon fusion with a cell, material associated with the bilayers of the non-phospholipid vesicle becomes incorporated into the outer membrane of the cell. Accordingly, a method for transmitting bilayer-associated material to a cell is also provided.
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Varanelli Carole
Wallach Donald F. H.
Eisenschenk Frank C.
Micro-Pak, Inc.
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