Lipid soluble forms of thiamine for prevention and treatment of

Details Lipid soluble forms of thiamine for prevention and treatment of Lipid soluble forms of thiamine for prevention and treatment of

1998-02-04

1999-03-23

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424427, 424430, 424433, 424434, 424436, 424439, 424451, 424464, A61F 202, A61F 606, A61F 902, A61K 948

Patent

active

058856080

ABSTRACT:
A method for preventing, ameliorating, and/or treating memory and other cognitive disorders associated with aging, such as Age-Associated Memory Impairment (also known as Age-Related Cognitive Decline), and other age-related impairments of, and/or changes in, cognitive function. The method comprises administering to a subject a therapeutically effective amount of a lipid-soluble thiamine or a prodrug thereof in an amount averaging from about 0.02 to about 0.5 grams per day per 70 kg body weight over a period of three months or longer.

REFERENCES:
Mimori et al, "Thiamine Therapy in Alzheimer's Disease", Metabolic Brain Disease, vol. 11, No. 1 pp. 89-94, 1996.
Lonsdale et al, "Brainstem Dysfunction in Infants Responsive to Thiamine Disulfide Preliminary Studies in Four Patients", Clinical Electroencephalography, vol. 13, No. 2, pp. 82-88, 1982.

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