Lipid replacement therapy

Details Lipid replacement therapy Lipid replacement therapy

1986-02-24

1989-03-14

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424422, 4284022, 436829, 514 78, 514878, 514879, A61K 31685, A61K 3722, B01J 1302

Patent

active

048123145

ABSTRACT:
A method of treating a relatively aged animal to reverse age-related changes in the lipid composition of organ and tissue cells, such as heart muscle cells, and the ability of the animal to withstand respiratory stress. A suspension of small unilamellar vesicles composed predominantly of egg phosphatidyl choline is administered parenterally to the animal, preferably over a period of several days and at a dose level of between about 0.1 and 1 grams lipid per kg body weight per day. Changes in the heart muscle cells are reflected in decreased levels of serum creatine phosphokinase. Liposome administration is continued until the serum creatine phosphokinase level drops at least about 50%. Also disclosed are liposome treatment methods for increasing longevity and male fertility.

REFERENCES:
patent: 4308166 (1981-12-01), Marchetti et al.
patent: 4310505 (1982-01-01), Baldeschwieler et al.
patent: 4544545 (1985-10-01), Ryan et al.
Kevin Jon Williams, Victoria P. Werth and John A. Wolff Intravenously Administered Lecithin Liposomes: A Synthetic Antiatherogenic Lipid Particle. Perspectives in Biology & Medicine, 27, 3 Spring 1984/417 thru p. 431.
Sanford O. Byers and Meyer Friedman, Transport of Cholesterol During Phosphatide-Induced Hypercholesterolemia. Biochim. Biophys. Acta, 125 (1966) 157-165.
Sanford O. Byers, Meyer Friedman and Toshiko Sugiyama, Mechanism Underlying Phosphatide-Induced Hypercholesterolemia, The Journal of Biological Chemistry, vol. 237, No. 11, Nov. 1962 printed in U.S.A.
Walter W. Stafford and Charles E. Day, The Upjohn Company, Kalamazoo, Mich. 49001 Artery 1(2):106-114 (1975) pp. 106-114.
A. N. Howard, J. Patelski, D. Bowyer & A. Gresham, Atherosclerosis Induced in Hypercholesterolaemic Baboons by Immunological Injury: and The Effects of Intravenous Polyunsaturated Phosphatidyl Choline. Atherosclerosis 1971 14:17-29.
J. Patelski, D. Bowyer, A. Howard, I. Jennings, C. Thorne & G. Gresham. Modification of Enzyme Activities in Experimental Atherosclerosis in the Rabbit. Atherosclerosis, 1970, 12: 41-53.
Meyer Friedman, Sanford O. Byers, and Ray H. Rosenman, "Resolution of Aortic Atherosclerotic Infiltration in the Rabbit by Phosphatide Infusion (23300)Lecithin (Animal) 90% Pure", purchased from Nutritional Biochemicals Corp. Cleveland, Ohio, pp. 586-588.
Barenholz, Y., et al, Biochemistry, 15:2441 (1976a).
Barenholz, Y., et al, in Enzymes in Lipid Metabolism (Gatt, S., et al, eds.), pp. 45-56. Plenum Press, NY (1976b).
Barenholz, Y., et al, Biochemistry, 16:2806 (1977).
Barenholz, Y., et al, Biochem Biophys Acta, 604:129 (1980).
Barenholz, Y., et al, in Phospholipids (Hawthorne, J. N., et al, eds.).
Barenholz, Y., in Physiology of Membrane Fluidity (Shinitsky, M.,) vol: 131-173, CRC Press, Boca Raton, FL (1984).
Cooper, R. A., et al, New England J Med, 297:371 (1977).
Frank, A., et al, Biochem, 22:5647 (1983).
Martin, F. J., et al, Biochem, 15:321 (1976).
Pagano, R. E., et al, in Research Monographs in Cell and Tissue Physiology (Dingle, J. T., et al, eds.), vol. 7, pp. 323-348 (1982).
Yechiel, E., et al, J Biol Chem, 260(16):9123 (1985a).
Yechiel, E., et al, J Biol Chem, 260(16):9131 (1985b).

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