Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1994-10-04
1997-05-20
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
264 43, 264 433, 4284022, A61K 9127
Patent
active
056310188
ABSTRACT:
A lipid-polymer conjugate for use in forming long-circulating liposomes is disclosed. The conjugate includes a vesicle-forming lipid having covalently attached to its polar head group, one of the polymers: polyvinylpyrrolidone, polyvinylmethylether, polyhydroxypropyl methacrylate, polyhydroxypropylmethacrylamide, polyhydroxyethyl acrylate, polymethacrylamide, polydimethylacrylamide, polymethyloxazoline, polyethyloxazoline, polyhydroxyethyloxazoline, polyhydroxypropyloxazoline, or polyaspartamide. A method for preparing liposomes containing the lipid-polymer conjugate is also disclosed.
REFERENCES:
patent: 5013556 (1991-05-01), Woodle, et al.
Weiner in `Advanced Drug Delivery Reviews`, vol. 3, pp.307-341, Published by `Elsevier Science Publishers`1989.
Decher et al. Angew. Makromol. Chem. 166-167, p.71, 1989 (Abstract only).
Lasic Danilo D.
Martin Francis J.
Woodle Martin C.
Zalipsky Samuel
Dehlinger Peter J.
Kishore Gollamudi S.
Mohr Judy M.
Sequus Pharmaceuticals, Inc.
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