Lipid phosphate phosphatases and uses thereof for treating...

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases

Reexamination Certificate

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C435S006120, C435S069100, C435S196000, C514S002600, C536S023200

Reexamination Certificate

active

07494645

ABSTRACT:
Lipid phosphate phosphatase proteins, genes coding for them, vectors and cells comprising them, antibodies directed against them, methods of identifying compounds binding to them and functional interactors as well as to the use of proteins, genes, vectors, cells, interacting compounds and functional interactors for treating neuronal diseases and/or injuries.

REFERENCES:
patent: WO 01/59063 (2001-08-01), None
patent: WO 02/22660 (2002-03-01), None
patent: WO 02/092798 (2002-11-01), None
patent: WO 03/057870 (2003-07-01), None
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Hooks et al. “Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent”,Journal of Biological Chemistry, vol. 276, No. 7, Feb. 16, 2001, pp. 4611-4621.
Brindley D N et al., “Lipid phosphate phosphatases regulate signal transduction through glycerolipids and sphingolipids”,Biochimica and Biophysica ACTA. Molecular and Cell Biology of Lipids, vol. 1582, No. 1-3, May 23, 2002, pp. 33-44.
Fukushima et al., “Lysophosphatidic acid (LPA) is a novel extracellular regulator of cortical neuroblast morphology”,Developmental Biology, vol. 228, No. 1, Dec. 1, 2000, pp. 6-18.
Brauer et al., “A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting”,Nature Neuroscience, vol. 6, No. 6, Jun. 20, 2003, pp. 572-578.

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