Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 8 to 10 amino acid residues in defined sequence
Reexamination Certificate
2007-01-30
2007-01-30
Saucier, Sandra E. (Department: 1651)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
8 to 10 amino acid residues in defined sequence
C530S345000, C530S300000, C435S212000, C435S176000, C435S177000
Reexamination Certificate
active
10754341
ABSTRACT:
The present invention relates to conjugates of a lipid, substrate peptide of an enzyme secreted from the cells of mammals, including humans, and a water-soluble polymer that can be used as colloidal carriers and the like of tissue-specific drug delivery systems, methods of producing these conjugates, peptide-water-soluble polymer conjugates optionally having protective groups that are useful as the intermediates of these conjugates, colloidal carriers made from these conjugates, and tissue-specific drug delivery systems that use these colloidal carriers.
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Bae M., et al.; Metalloprotease-specific Poly(ethylene glycol) Methyl Ether-Peptide-Doxonrubicin Conjugate for Targeting Anticancer Drug Delivery Based on Angiogenesis; Drug Exp. Clin. Res., 2003, vol. 29; No. 1, pp. 15-23.
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Miyazaki K., et al.; Sosetsu, Matrix Metalloproteinase; their structures and functions, with special reference to their roles in tumor invasion and metastasis; Seikagaku, Dec. 25, 1996; vol. 68; No. 12, pp. 1791-1807.
Atsushi Maeda
Saito Katsumi
Takagi Akira
Yamashita Noboru
Yoshioka Tatsnobu
Astellas Pharma Inc.
Barnhart Lora E
Saucier Sandra E.
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