Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1994-05-13
1997-09-09
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424484, 424489, 424490, 424498, 424502, 4284022, 264 41, 264 43, A61K 9127, A61K 914
Patent
active
056653794
ABSTRACT:
The invention relates to a lipid particle forming matrix, characterized by, that from a defined system of at least two lipid components chosen from classes of different polarity, in which at least one of the lipid components is bilayer forming, discrete lipid particles are formed spontaneously when interacting with aqueous systems. Preferably at least one of the lipid components is amphiphatic and polar and one is nonpolar. These discrete particles are formed spontaneously from the matrix without any chemical or physical treatment or initiation. The invention also relates to a process for producing the matrix and use thereof.
REFERENCES:
patent: 4610868 (1986-09-01), Fountain et al.
patent: 4877561 (1989-10-01), Iga et al.
patent: 4963367 (1990-10-01), Ecanow
Kim et al., Studies on Liposome-Encapsulated Heparin, Diolog File 154: Medline, 1985-1993.
Kim et al., Studies on Liposome-Encapsulated Heparin, Abstract, Thrombosis Research, vol. 43 (1986), pp. 603-612.
Bates, et al., Bioavailability of Micronized Griseofulvin from Corn Oil-in-Water Emulsion, Aqueous Suspension, and Commercial Tablet Dosage Forms in Humans, Journal of Pharmaceutical Sciences, vol. 64, No. 5, May 1975, pp. 793-797.
Palin, et al., The oral absorption of cefoxitin from oil and emulsion vehicles in rats, International Journal of Pharmaceutics, 33 (1986), pp. 99-104.
Patel, et al., Oral Administration of Insulin by Encapsulation within Liposomes, FEBS Letters, vol. 62, Nol. 1 (1976), pp. 60-63.
Flynn, Oral Delivery of Insulin, The Lancet (1989), pp. 1518-1519.
Tarr, et al., Enhanced Intestinal Absorption of Cyclosporine in Rats Through the Reduction of Emulsion Droplet Size, Pharmaceutical Research, vol. 6, No. 1 (1989), pp. 40-43.
Illum, et al., Enhanced nasal absorption of insulin in rats using lysophosphatidylcholine, Int. Jour. of Pharm., 57 (1989), pp. 49-54.
Woolfrey, et al., The effect of Miglyol 8 12 oil on the oral absorption of propranolol in the rat, J. Pharm. Pharmacol., vol. 41 (1989), pp. 579-581.
Winn, et al., The Bioavailability of a Mixed Micellar Preparation of Vitamin K.sub.1, and its Procoagulant Effect in Anticoagulated Rabbits, J. Pharm. Pharmacol., vol. 41 (1989), pp. 257-260.
Rowland, et al., The Stability of Liposomes in Vitro to pH, Bile Salts and Pancreatic Lipase, Biochemica et Biophysica Acta, 620 (1980), pp. 400-409.
Manosroi, et al., Thermodynamic Characteristics of a Human Insulin-Deae-Dextran Complex Entrapped in Liposomes, Drug Develop. and Industrial Pharmacy, vol. 16, No. 5 (1990), pp. 837-854.
Weiner, et al., Liposomes as a Drug Delivery System, Drug Devel. and Industrial Pharmacy, vol. 15, No. 10 (1989), pp. 1523-1554.
Payne, et al., Characterization of Proliposomes, Journal of Pharm. Sciences, vol. 75, No. 4, (1986), pp. 330-333.
Herslof Bengt
Nicklasson Alf Gunnar Martin
Kishore Gollamudi S.
Pharmacia & Upjohn Aktiebolag
LandOfFree
Lipid particle forming matrix, preparation and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Lipid particle forming matrix, preparation and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lipid particle forming matrix, preparation and use thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-67743