Lipid-nucleic acid particles prepared via a hydrophobic lipid-nu

Details Lipid-nucleic acid particles prepared via a hydrophobic lipid-nu Lipid-nucleic acid particles prepared via a hydrophobic lipid-nu

1996-06-06

1999-11-02

Degen, Nancy

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

435458, 514 44, A61K 9127, A61K 3170, C12N 1588

Patent

active

059765674

ABSTRACT:
Novel lipid-nucleic acid particulate complexes which are useful for in vitro or in vivo gene transfer are described. The particles can be formed using either detergent dialysis methods or methods which utilize organic solvents. Upon removal of a solubilizing component (i.e., detergent or an organic solvent) the lipid-nucleic acid complexes form particles wherein the nucleic acid is serum-stable and is protected from degradation. The particles thus formed have access to extravascular sites and target cell populations and are suitable for the therapeutic delivery of nucleic acids.

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