Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
1999-11-01
2008-09-09
Zara, Jane (Department: 1635)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S006120, C435S091100, C435S091310, C514S04400A, C536S023100, C536S024500, C424S450000
Reexamination Certificate
active
07422902
ABSTRACT:
Novel lipid-nucleic acid particulate complexes which are useful for in vitro or in vivo gene transfer are described. The particles can be formed using either detergent dialysis methods or methods which utilize organic solvents. Upon removal of a solubilizing component (i.e., detergent or an organic solvent) the lipid-nucleic acid complexes form particles wherein the nucleic acid is serum-stable and is protected from degradation. The particles thus formed have access to extravascular sites and target cell populations and are suitable for the therapeutic delivery of nucleic acids.
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Bally Marcel B.
Cullis Pieter R.
Hope Michael
Reimer Dorothy L.
Scherrer Peter
Seed IP Law Group PLLC
The University of British Columbia
Zara Jane
LandOfFree
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