Lipid nano-pellets as excipient system for perorally administere

Details Lipid nano-pellets as excipient system for perorally administere Lipid nano-pellets as excipient system for perorally administere

1987-06-26

1989-11-14

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424502, 514786, A61K 3722, A61K 950, A61K 4700

Patent

active

048806340

ABSTRACT:
An excipient system containing a drug for peroral administration in the form of an ultrafine aqueous, colloidal suspension of lipid nano-pellets comprised of lipids and a surfactant of which the particle diameters of the nano-pellets range from 50-1,000 nm, preferably from 80-800 nm, the ratio of lipid to surfactant in the lipid nano-pellets ranging from 1:0.1 to 1:2.2, preferably from 1:0.22 to 1:1.2, especially from 1:1 to 1:0.22, and where the lipid nano-pellets are present in the suspension in a concentration of from 1-20% by weight. The lipid nano-pellets can be provided with pharmacologically active substances, making possible improved biological availability upon peroral administration.

REFERENCES:
patent: 4115313 (1978-09-01), Lyon et al.
patent: 4331654 (1982-05-01), Morris
patent: 4356167 (1982-10-01), Kelly
patent: 4372949 (1983-02-01), Kodama et al.
Chemical Abstracts 80,52392a (1974).

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