Lipid lowering alkylene glycols and ester derivatives thereof

Details Lipid lowering alkylene glycols and ester derivatives thereof Lipid lowering alkylene glycols and ester derivatives thereof

1979-04-23

1981-06-23

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424308, 424311, 424312, 424340, 546318, 560107, 560255, 560108, 568641, C07D21380, C07C 6990, A61K 31455, A61K 3160

Patent

active

042750687

ABSTRACT:
Novel alkylene glycol derivatives of the formula (1) ##STR1## in which R.sup.1 is the hydrogen atom, an alkyl group having 1-4 C-atoms or an aryl group, R.sup.2 is the hydrogen atom or an alkyl group having 1-4 C-atoms, R.sup.3 is the hydrogen atom or a group of the formula ##STR2## in which Z is an alkyl residue, an optionally substituted aryl residue or a heterocyclic residue and R.sup.4 is a residue of the formula ##STR3## in which R.sup.5 is the hydrogen atom or chlorine atom, or the methyl group, exhibit an advantageous activity in regard of lowering the cholesterol and triglyceride level in the blood. Production of the novel derivatives by reduction of the corresponding acids, or by reacting a phenol of the formula ##STR4## and an alcohol of the formula ##STR5## optionally with subsequent esterification, is described.

REFERENCES:
patent: 3969419 (1976-07-01), Engel et al.
patent: 4042594 (1977-08-01), Irikura
Thummler et al., Chem. Abstracts, vol. 54, p. 25789 g-h 1960.

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