Lipid kinase

Details Lipid kinase Lipid kinase

1997-11-25

1999-03-16

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435 691, 4352523, 4353204, 435 77, 435 692, 530350, 536 232, 536 235, C12N 912, C12N 120, C12P 2106, C07H 2104

Patent

active

058829105

ABSTRACT:
The present invention generally relates to a novel catalytic subunit of a lipid kinase designated p110.delta.. Polynucleotides encoding p110.delta. and recombinant p110.delta. polypeptides are provided along with antibodies to p110.delta., assays for identifying inhibitors of p110.delta., and the like.

REFERENCES:
patent: 4766046 (1988-08-01), Abra et al.
patent: 5169637 (1992-12-01), Lenk et al.
patent: 5180713 (1993-01-01), Abra et al.
patent: 5185154 (1993-02-01), Lasic et al.
patent: 5204112 (1993-04-01), Hope et al.
patent: 5252263 (1993-10-01), Hope et al.
patent: 5480906 (1996-01-01), Creemer et al.
Burgering and Coffer, "Protein Kinase B (c-Akt) in Phosphatidylinositol-3-OH Kinase Signal Transduction," Nature, 376:599-602 (1995).
Capecchi, M.R., "Altering the Genome by Homologous Recombination," Science, 244:1288-1292 (1989).
Eichholtz et al., "A Myristoylated Pseudosubstrate Peptide, a Novel Protein Kinase C Inhibitor," J. Biol. Chem., 268:1982-1986 (1993).
Fraser et al., "Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28," Science, 251:313-316 (1991).
Godiska et al., "Chemokine Expression in Murine Experimental Allergic Encephalomyelitis," J. Neuroimmun., 58:167-176 (1995).
Hiles et al., "Phosphatidylinositol 3-Kinase: Structure and Expression of the 110 kd Catalytic Subunit," Cell, 70:419-429 (1992).
Hu et al., "Cloning of a Novel, Ubiquitously Expressed Human Phosphatidylinositol 3-Kinase and Identification of its Binding Site on p85," Mol. Cell. Biol., 13:7677-7688 (1993).
Hu et al., "Ras-Dependent Induction of Cellular Responses by Constitutively Active Phosphatidylinositol-3 Kinase," Science, 268:100-102 (1995).
Hunter, T., "When is a Lipid Kinase Not a Lipid Kinase? When it is a Protein Kinase," Cell, 83:1-4 (1995).
Kozak, M., "An Analysis of Vertebrate mRNA Sequences: Intimations of Translational Control," J. Cell. Biol., 115:887-992 (1991).
Otsu et al., "Characterization of Two 85 kd Proteins that Associate with Receptor Tyrosine Kinases, Middle-T/pp60.sup.c-src Complexes, and PI3-Kinase," Cell, 65:91-104 (1991).
Pages et al., "Binding of Phosphatidyl-inositol-3-OH Kinase to CD28 is Required for T-cell Signalling," Nature, 369:327-329 (1994).
Panayotou and Waterfield, "Phosphatidyl-inositol 3-kinase: A Key Enzyme in Diverse Signalling Processes," Trends in Cell Biol., 2:358-360 (1992).
Parker, P.J., "PI 3-kinase puts GTP on the Rac," Current Biology, 5:577-579 (1995).
Rameh et al., "Phosphatidylinositol (3,4,5)P.sub.3 Interacts with SH2 Domains and Modulates PI 3-Kinase Association with Tyrosine-Phosphorylated Proteins," Cell, 83:821-830 (1995).
Rodriguez-Viciana et al., "Activation of Phosphoinositide 3-Kinase by Interaction with Ras and by Point Mutation," EMBO Journal., 15:2442-2451 (1996).
Rudd, C.E., "Upstream-Downstream: CD28 Cosignaling Pathways and T Cell Function," Immunity, 4:527-534 (1996).
Sambrook et al., 9.47-9.51 in Molecular Cloning, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, (1989).
Stephens et al., "Characterization of a Phosphatidylinositol-Specific Phosphoinositide 3-kinase from Mammalian Cells," Current Biology, 4:203-214 (1994).
Stoyanov et al., "Cloning and Characterization of a G Protein-Activated Human Phosphoinositied-3 Kinase," Science, 269:690-693 (1995).
Thelan et al., "Wortmannin Binds Specifically to 1-phosphatidylinositol 3-kinase While Inhibiting Guanine Nucleotide-binding Protein-coupled Receptor Signaling in Neutrophil Leukocytes," Proc. Natl. Acad. Sci. USA., 91:4960-4964 (1994).
Volinia et al., "Chromosomal Localization of Human p85.alpha., a Subunit of Phosphatidylinositol 3-kinase, and its Homologous p85.beta.," Oncogene, 7:789-793 (1992).
Yao and Cooper, "Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor," Science, 267:2003-2006 (1995).
Chantry, D. et al., "p110.delta., a Novel Phosphatidylinositol 3-Kinase Catalytic Subunit That Associates with p85 and Is Expressed Predominantly in Leukocytes," J. Biological Chemistry, 272(31):19236-19241 (Aug. 1, 1997).
Genbank Accession No. U57843, "Human phosphatidylinositol 3-kinase delta catalytic subunit mRNA," deposited by Morris, A.J., dated May 10, 1997.
Vanhaesebroeck, B. et al, "p110.delta., a novel phosphoinositide 3-kinase in leukocytes," Proc. Natl. Acad. Sci., USA, 94:4330-4335 (Apr. 1997).
Volinia, S. et al., "A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system," EMBO J., 14(14):3339-3348 (1995).
Hu, P. et al., "Cloning of a Novel, Ubiquitously Expressed Human Phosphatidylinositol 3-Kinase and Identification of Its Binding Site on p85," Molecular and Cellular Biology, 13(12):7677-7688 (1993).

Affiliated with

Also associated with

Rating

Lipid kinase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Lipid kinase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lipid kinase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-816661