Lipid encapsulated hemoglobin cells

Details Lipid encapsulated hemoglobin cells Lipid encapsulated hemoglobin cells

1978-02-10

1979-01-09

Fagelson, Anna P.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

252316, 424101, 424365, A61K 942, A61K 950, A61K 3514, A61K 3518

Patent

active

041338740

ABSTRACT:
Synthetic erythrocytes. Hemoglobin is encapsulated in lipid materials to form cells which are typically 0.1 to 10 microns in their greatest dimension. Preferably cholesterol and one or more phospholipids are included in the cell membrane. The lipid membrane is of such character and thinness that O.sub.2 --CO.sub.2 transfer thereacross is readily accomplished. The preferred encapsulation process utilizes ultrasonic energy.

REFERENCES:
patent: 3887698 (1975-06-01), McConnell
Koszo, Biochem. & Biophys, Acta, vol. 363, 1974, pp. 182-189.
Papahadjopoulos, Biochem. & Biophys. Acta, vol. 363, 1974, pp. 408-418.
Nicholls, Biochem. & Biophys. Acta, vol. 363, 1974, pp. 190-201.
Merck Index, Merck & Co., Rahway, N.J., 7th Ed., 1960, pp. 245, 509.
Gregoriadis, Febs Letters, vol. 36, No. 3, Nov. 1973, pp. 292-296.
Calissano, Biochem. & Biophys, Res. Comm., vol. 43, 1971, pp. 504-509.
Schubert, Chem. Abs., vol. 79, 1973, Ab. No. 122811s.

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