Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1994-03-14
1995-10-24
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
252309, 252312, 514552, 514938, A61K 31685, A61K 3123, B01J 1300
Patent
active
054610370
ABSTRACT:
A lipid emulsion is provided comprising water, an emulsifier, and a glyceride oil component. The weight ratio of the emulsifier to glyceride oil is approximately 0.04 to about 0.01. It has been found that intravenous lipid emulsions having a weight ratio of emulsifier to glyceride oil of approximately 0.04 to about 0.01 are more rapidly metabolically utilized.
REFERENCES:
Carpentier et al, Parameters for Evaluation of Lipid Metabolism, Journal of Parenteral and Enteral Nutrition, vol. 11, No. 5 (Suppl.), pp. 104S-108S (1987).
Carpentier et al, Interactions between Exogenous Fat and Plasma/Lipoproteins, Infusionstherapie 14:suppl. 3, pp. 29-32 (1987).
Untracht, Intravascular Metabolism of an Artificial Transporter of Triacylglycerols/Alterations of Serum Lipoproteins Resulting from Total Parenteral Nutrition with Intralipid, Biochimica et Biophysica Acts, 711, 176-192 (1982).
Griffin et al, Appearance and Characterization of Lipoprotein X during Continuous Intralipid Infusions, in the Neonate, J. Clin. Invest. vol. 64, pp. 1703-1712 (1979).
Haumont et al., Tolerance of Premature Infants to 10 and 20% 8th Congress of the European Society of Parenteral and Enteral Nutrition, vol. 8, No. 5 (1984).
Tashiro et al, Alteration of Lipoprotein Profile during Total Parenteral Nutrition with Intralipid 10%, Journal of Parenteral and Enteral Nutrition, vol. 10, No. 6, pp. 62214 626 (1986).
Rigaud et al, Quantification of Lipoprotein X and its Relationship to Plasma Lipid Profile during Different Types of Parenteral Nutrition, Journal of Parenteral and Enteral Nutrition, vol. 8, No. 5, pp. 529-534 (1984).
Carpentier et al, Effects of Infusion Rate and Phospholipid Content of Fat Emulsions in Man, Clinical Nutrition, 5 (Suppl.) p. 43 (1986).
Clintec Nutrition Company
Lovering Richard D.
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