Lipid emulsion

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

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252309, 252312, 514552, 514938, A61K 31685, A61K 3123, B01J 1300

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active

057600201

ABSTRACT:
A lipid emulsion is provided comprising water, an emulsifier, and a glyceride oil component. The weight ratio of the emulsifier to glyceride oil is approximately 0.04 to about 0.01. It has been found that intravenous lipid emulsions having a weight ratio of emulsifier to glyceride oil of approximately 0.04 to about 0.01 are more rapidly metabolically utilized.

REFERENCES:
patent: 3169094 (1965-02-01), Wretlind
patent: 4280996 (1981-07-01), Okamoto et al.
patent: 4678808 (1987-07-01), Ward et al.
patent: 5461037 (1995-10-01), Cotter
Haumont et al, Tolerance of Premature Infants to 10 to 20% LCT Fat Emulsions, 8th Congress of the European Society of Parenteral and Enteral Nurtrition (1986).
Tashiro et al, Alteration of Lipoprotein Profile during Total Parenteral Nutrition with Intralipid 10%, Journal of Parenteral and Enteral Nutrition, vol. 10, No. 6, pp. 622-626 (1986).
Rigaud et al, Quantification of Lipoprotein X and its Relationship to Plasma Lipid Profile during Different Types of Parenteral Nutrition, Journal of Parenteral and Enteral Nurtition, vol. 8, No. 5, pp. 529-534 (1984).
Carpentier et al, Effect of Infusion Rate and Phospholipid Content of Fat Emulsions in Man, Clinical Nutrition, 5 (Suppl), p. 43 (1986).
Carpentier et al, Parameters for Evaluation of Lipid Metabolism, Journal of Parenteral and Enteral Nutrition, vol. 11, No. 5 (Suppl.), pp. 104S-108S (1987).
Carpentier et al, Interactions between Exogenous Fat and Plasma/Lipoproteins, Infusionstherapie 14:suppl. 3, pp. 29-32 (1987).
Griffin et al, Appearance and Characterization of Lipoprotein X during Continuous Intralipid Infusions in the Neonate, J. Clin. Invest, vol. 64, pp. 1703-1712 (1979).
Bettner et al., "Effects of pH, Temperature, Concentration and Time on Particle Counts in Lipid-Containing Total Parenteral Nutrition Admixtures" in J. Parenter. Enteral Nutr., vol. 10, No. 4. pp. 375-380 (1986).
Carlson, L.A. et al., "A Methodological Study of an Intravenous Fat Tolerance Test with Intralipid.RTM. Emulsion," in Scand. J/ clin. Lab. Invest. 29, pp. 271-280, 1972.
Carneheim, C. "Elimination Rate of Three LCT Emulsions Containing 10, 20 and 30% Triglycerides in the Rat," in Clinical Nutrition, vol. 9, p. 31. (1990).
Carpentier, et al., "Effect of Infusion Rate and Phosolipid Content of Fat Emulsions," in Clin. Nutr., vol. 5, pp. 43, 1986.
Carpentier et al., "Fat Emulsions are More than Energy Suppliers," in Infusionstherapie, vol. 13, pp. 182-184, 1986.
Carpentier et al., "Interactions between Exogenous Fat and Plasma/Lipoproteins," in Infusionstherapie, vol. 14, pp. 29-32, 1987.
Carpentier et al., "New Developments in Fat Emulsions," in Proceedings of the Nutrition Society, vol. 49, pp. 375-380, 1990.
Carpentier et al. "Paramenters for Evaluation of Lipid Metabolism," in Journal of Parenteral and Enteral Nutrition, vol. 11, No. 5, pp. 104S-108, 1987.
Cotter et al., "Evaluation of the Elimination Kinetics of 3 Soybean-based Lipid Emulsions with Varying Phospholipid to Oil Ratios," in J. Clin., Nutr., vol. 46, No. 3, 1987.
Dahlan et al., "Effects of Essential Fatty Acid Contents of Lipid Emulsions on Erythrocyte Polyunsaturated Fatty Acid Composition in Patients on Long-Term Parenteral Nutrition," in Clin. Nutr., vol. 11, pp. 262-268, 1992.
Dahlan et al., Modification of Erythrocyte Membrane Lipid Composition Induced by a Single Intravenous Infusion of Phospholipid-Triacylglycerol Emulsions in Man, in Clin. Nutr., vol. 11, pp. 255-261, 1992.
duPlessis et al., The Stability of Parenteral Fat Emulsions in Nutrition Mixtures, in J. Clin. Pharm. Ther., vol. 12, pp. 307-318, 1987.
Griffin, E. et al., "Appearance and Characterization of Lipoprotein X during Continuous Intralipid Infusions in the Neonate," in J. Clin. Invest., vol. 64, pp. 1703-1712, Dec. 1979.
Haumont et al., "Effects on Liposomal Content of Lipid Emulsions on Plasma Lipid Concentrations in Low Birth Weight Infants Receiving Parenteral Nutrition," in J. Pediatr., vol. 121, pp. 759-763, 1992.
Haumont et al., "Plasma Lipid and Plasma Lipoprotein Concentrations i Low Birth Weight Infants Given Parenteral Nutrition with 20% Compared to 10% Intralipid,"in J. Pediatr., vol. 115, pp. 787-793, 1989.
Haumont et al., "Total Parenteral Nutrition in Low Birth Weight Infants: Effect of the Same Liposomal Content in 10% and 20% Lipid Emulsions on Plasma Lipids and Lipoproteins," in Experiences With a Modified 10% Fat Emulsion, Carpentier et al. eds., W. Zuckschwerdt Verlag, Munich, 1993.
Jeejeebhoy et al., "Metabolic Studies in Total Parenteral Nutrition with Lipid in Man, Comparison with Glucose," in J. Clin. Invest. vol. 57, pp. 125-136, 1976.
Lewis., B. et al., "Determination of the Intravenous Fat Tolerance Test with Intralipid.RTM. by Nephelometry," in Artherosclerosis, vol. 15, pp. 83-86, 1972.
Lindh, Annika et al., "Immediate Intralipid Clearance from Plasma in Critically I11 Patients after a Single-Dose Injection," in Critical Care Medicine, vol. 15, No. 9, pp. 826-830, 1987.
"A New Red-Sensitive Micronephelometer," Technical Note in Med. & Biol. Engng. vol. 5, pp. 51-56, 1967.
Niemiec et al., "Compatibility Considerations in Parenteral Nutrient Solutions," in Am. J. Hosp. Pharm., vol. 41, pp. 893-911, 1984.
Rigaud, M.D., D., et al. "Quantification of Lipoprotein X and its Relationship to Plasma Lipid Profile During Different Types of Parenteral Nutrition," i Journal of Parenteral and Enteral Nutrition, vol. 8, No. 5, 00. 529-534, 1986.
Tannuri et al., "Must Fat Emulsions and Parenteral Nutrition Solutions Be Given Through Separate Circuits?" in J. Pediar. Surg., vol. 22, 132-134, 1987.
Tashiro, M.D. Tsuguhiko et al. "Alteration of Lipoprotein Profile During Total parenteral Nutrition with Intralipid 10%," in Journal of Parenteral and Enteral Nutrition, vol. 10, No. 6., pp. 622-626, 1986.
Untracht, Steven J., "Intravascular Metabolism of an Artificial Transporter of Triacylglycerols; Alterations of Serum Lipoproteins Resulting From Total Parenteral Nutrition With Intralipid," in Biochemic et Biophysica Acta., 711, pp. 176-192, 1982.
Van Buskirk et al., "Scaleup of Liquid and Semisolid Disperse Systems," in Pharmaceutical Research, vol. 11, pp. 1216-1220, 1994.

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