Lipid derivatives

Details Lipid derivatives Lipid derivatives

1988-11-29

1991-09-10

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546170, 546168, 546148, C07D40306, C07D21510

Patent

active

050475401

ABSTRACT:
Lipid derivatives represented by the formula: ##STR1## wherein R.sub.1 is alkyl or alkylcarbamoyl; R.sub.2 is lower alkyloxy, lower alkylcarbamoyloxy, lower alkylcarbonylamino, lower alkyloxycarbonylamino, lower alkylureido, lower alkyloxymethyl, lower alkylcarbonylmethyl, cyanomethyl, heterocyclic group, or he0 terocyclyloxy; R.sub.2 ' is hydrogen or R.sub.2 and R.sub.2 ' taken together form --O(CH.sub.2).sub.m -- wherein m is an integer of 1 to 5; R.sub.3, R.sub.4, and R.sub.5 each is hydrogen or lower alkyl or two or three of R.sub.3, R.sub.4, and R.sub.5 taken together with the adjacent nitrogen atom form cyclic ammonio; R.sub.6 is hydrogen or lower alkylcarbonyl; X.sup.- is a counter anion; Y is oxygen or sulfur; and n is an integer of 1 to 10, being useful as PAF antagonists, e.g., as antithrombotic, antivasoconstricting, antibronchoconstricting agent or antitumor agent.

REFERENCES:
patent: 3920739 (1975-11-01), Suda et al.
patent: 4061639 (1977-12-01), Goralski
patent: 4097669 (1978-06-01), Reisdorff
patent: 4267122 (1981-05-01), Thil et al.
patent: 4329289 (1982-05-01), Fahrenholtz et al.
patent: 4471116 (1984-09-01), Davidson et al.
patent: 4539408 (1985-09-01), Kampfer et al.
patent: 4762848 (1988-09-01), Scheunnemann et al.

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