Lipid constructs for targeting to vascular smooth muscle tissue

Details Lipid constructs for targeting to vascular smooth muscle tissue Lipid constructs for targeting to vascular smooth muscle tissue

1995-02-10

1997-08-26

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

514 71, 514 9, 514 24, A61K 9127, A61K 3816, A61K 3800, A61K 3170

Patent

active

056608551

ABSTRACT:
A lipid construct comprising an aminomannose derivatized cholesterol suitable for targeting smooth muscle cells and tissue. Preferred formulations contain 6-(cholest-5-en-3.beta.-yloxyl)hexyl-6-amino-6-deoxy-1-thio-.alpha.-D-mann opyranoside in liposome formulations wherein the formulations are delivered generally to arteries using percutaneous transluminal coronary angioplasty procedures. These formulations have applications in the reduction of restenosis.

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