Lipid cleavage enzyme

Details Lipid cleavage enzyme Lipid cleavage enzyme

2007-02-13

2007-02-13

Lankford, Jr., Leon B. (Department: 1651)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S197000

Reexamination Certificate

active

10211260

ABSTRACT:
A membranous enzyme not yet described in the state-of-the-art can be extracted from cellular membrane fractions of blood leukocytes or monocytes/macrophages. Also disclosed is the use of substrates of this enzyme to prepare medicaments that contain these substrates as pharmaceutical active substance. These medicaments are useful to direct pharmacologically active substances to target cells and to enrich target cells with said substances. Also disclosed are in-vitro research systems containing this enzyme used to detect other substrates of this enzyme.

REFERENCES:
patent: 5512671 (1996-04-01), Piantadosi et al.
patent: 6077837 (2000-06-01), Kozak
patent: WO 9119726 (1991-12-01), None
Warren et al. “Three-peaked chemiluminescent response of human peripheral blood leukocytes following stimulations with phytohaemagglutinin (PHA),” J. Biolum. Chemilum. (1990) 5: 235-241.
Record et al. “A rapid isolation procedure of plasma membranes from human neutrophils using self-generating Percoll gradients. Importance of pH in avoiding contamination by intracellular membranes” Biochim. Biophys. Acta (1985) 819: 1-9.
Hostetler et al., “Synthesis and Antiretroviral Activity of Phospholipid Analogs of Azidothymidine and Other Antiviral Nucleosides” (1990) J. Biol. Chem., 265(11), 6112-6117.
Piantadosi et al., “Synthesis and Evaluation of Novel Ether Lipid Nucleoside Conjugates for Anti-HIV Activity” (1991) J. Med. Chem., 34(4), 1408-1414.
Davitz et al., “Purification of a Glycosyl-phospatidylinositol-specific Phospholipase D from Human Plasma” (1989) J. Biol. Chem., 264(23), 13760-13764.

Affiliated with

Also associated with

Rating

Lipid cleavage enzyme does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Lipid cleavage enzyme, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lipid cleavage enzyme will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3811829