Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1996-07-31
1998-04-07
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514282, 514558, 546 45, 562450, A01N 3700
Patent
active
057365733
ABSTRACT:
Amine compound derivatives enhancing the transdermal delivery (skin penetration) of pharmacologically active substances (drugs). In order to pass through the skin more effectively, the present invention provides derivatives that are soluble or miscible, or compatible with both lipids and water. These derivatives are formed by combining a drug of the amine class (to which most drugs belong) with a lipid-soluble long-chain acid such as oleic, linoleic, stearic, myristic, or palmitic acid.
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Gummer, C.L. in Percutaneous Absorption: Mechanisms-Methodology-Drug Delivery, Marcel Dekker Inc., edited by Bronaugh, R.L. et al, pp. 561-570, Jan. 1987.
Morrison, R.T., et al, Organic Chemistry, 4th edition, Allyn & Bacon Inc., 1983, pp. 891 and 926.
Dahlen Garth M.
Ivy C. Warren
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