Lipid amines formulated with fat or lipid emulsions as vaccine a

Details Lipid amines formulated with fat or lipid emulsions as vaccine a Lipid amines formulated with fat or lipid emulsions as vaccine a

1979-10-26

1982-01-12

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424 88, 424199, 424325, 424330, 424358, A61K 3113, A61K 31685, A61K 3900, A61K 4700

Patent

active

043105505

ABSTRACT:
N,N-higher alkyl-N',N'-bis(2-hydroxyethyl)propanediamines and N,N-higher alkyl-xylylenediamines formulated with fat or lipid emulsions are useful as vaccine adjuvants of low toxicity. These compositions are useful in conjunction with known immunological substances in order to induce or enhance the immunogenic response. Preferred compositions employ N,N-higher alkyl-N',N'-bis(2-hydroxyethyl)propanediamines, particularly N,N-dioctadecyl-N',N'-bis(2-hydroxyethyl)propanediamine in Intralipid.

REFERENCES:
patent: 3169094 (1965-02-01), Wrettind
patent: 3872171 (1975-03-01), Cronin et al.
patent: 4034040 (1977-07-01), Cronin et al.
patent: 4173641 (1979-11-01), Kraska
Gall, Immunology 11, pp. 369-386, (1966).
Strannegard et al.; Int. Arch Allergy appln. Immun. 51, pp. 198-205 (1976).
"Immunological Adjuvants", World Health Organization Technical Report Series No. 595 (1976).
Fortner et al., Am. J. Hosp. Pharm. 32, pp. 582-584 (1975).
Chang and Pearson, Arth. Rheum. 21, pp. 169-170 (1978).

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