Lipid A derivatives

Details Lipid A derivatives Lipid A derivatives

1990-01-19

1991-08-20

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 62, 536 22, 536115, 536116, 536117, 536119, 536120, 536 53, 536 55, 536 187, A61K 3100, C07H 2100, C07H 1300, C07H 500

Patent

active

050414275

ABSTRACT:
Compounds are disclosed which are useful in a method of treating animals to protect them from the toxic effects of Gram negative endotoxin. They include the diphosphoryl lipid A (DPLA) which can be obtained from R. sphaeroides ATCC 17023 grown at about 26.degree. C.

REFERENCES:
patent: 4746742 (1988-05-01), Hasegawa et al.
Eur. J. Biochem., 180. 519-526 (1989), "Structural Analysis of the Nontoxic Lipid A of Rhodobacter Capsulatus 37b4", Jurgen H. Krauss et al.
Imoto, M., S. Kusumoto, T. Shiba, E. Th. Rietschel, C. Galanos, and O. Luderitz, 1985, Chemical Structure of Escherichia coli lipid A., Tetrahedron Lett. 26: 907-908.
Qureshi, N., K. Takayama, P. Mascagni, J. Honovich, R. Wong, and R. J. Cotter, 1988. Complete Structural Determination of Lipopolysaccharide Obtained from Deep Rough Mutant of Escherichia coli., Purification by High Performance Liquid Chromatography and Direct Analysis by Plasma Desorption Mass Spectrometry., J. Biol. Chem. 263: 11971-11976.
Salimath, P. V., R. N. Tharanathan, J. Weckesser, and H. Mayer, 1983, Structural Studies on the Non-Toxic Lipid A from Rhodopseudomonas sphaeroides ATCC 17023., Eur J. Biochem, 136: 195-200.
Salimath, P. V., R. N. Tharanathan, J. Weckesser, and H. Mayer, 1984, The Structure of the Polysaccharide Moiety of Rhodopseudomonas sphaeroides, ATCC 17023 Lipopolysaccharide, Eur. J. Biochem, 144: 227-232.
Chemical Abstract, vol. 97, No. 11, 1982, Van Boeckel et al., "Chemical Synthesis of Diphosphorylated Lipid A Derivatives", the Abstract No. 92667b, Tetrahedron Lett. 1982, 23 (18), 1951-54 (Eng).
Chemical Abstract, vol. 100, No. 15, 1984, Van Boeckel et al., "Synthesis of Two Diphosphorylated Lipid A Derivatives Containing Alpha or Beta-Anomeric Phosphates", the Abstract No. 121493e, Recl.: J. R. Neth. Chem. Soc. 1983, 102 (10), 438-49 (Eng).
Strittmatter et al., "Nontoxic Lipopolysaccharide from Rhodopseudomonas sphaeroides, ATCC 17023," Journal of Bacteriology, Jul. 1983, pp. 153-158.
Cotter et al., "Structural Determination of Lipid A from Gram Negative Bacteria Using Laser Desorption Mass Spectrometry," Biomedical and Environmental Mass Spectrometry, vol. 14, pp. 591-598 (1987).
Takayama et al., "Diphosphoryl Lipid A from Rhodopseudomonas sphaeroides, ATCC 17023", Blocks Induction of Cachectin in Macrophages by Lipopolysaccharide, Infection and Immunity, Apr. 1989, pp. 1336-1338.

Affiliated with

Also associated with

Rating

Lipid A derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Lipid A derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lipid A derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1008010