Lipid A deficient mutants of Neisseria meningitidis

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...

Reexamination Certificate

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C424S250100, C424S093400, C424S093200, C424S184100

Reexamination Certificate

active

07438918

ABSTRACT:
The invention provides lipid A deficient mutantNeisseria meningitidiscells, pharmaceutical compositions incorporating such cells, and methods of using such cells.

REFERENCES:
patent: 4533630 (1985-08-01), Wilkins et al.
patent: 4559157 (1985-12-01), Smith et al.
patent: 4608392 (1986-08-01), Jacquet et al.
patent: 4820508 (1989-04-01), Wortzman
patent: 4992478 (1991-02-01), Geria
patent: 5976536 (1999-11-01), Stephens et al.
patent: 184187 (1986-06-01), None
patent: WO 01/09350 (2001-08-01), None
Granoff et al. Vaccine 11: S46-S51, 1993.
“AF428103—Neisseria meningitidisacyl-transferase MsbB (msbB) gene, complete”,Genbank Accession Number, Entrez Nucleotide—NCBI, (Feb. 2002), 2 pages.
Apicella, Michael A., “Gram-Negative Cocci”,Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, Gerald L. Mandell; R. Gordon Douglas; John E. Bennett; Raphael Dolin, 5th ed. Philadelphia : Churchill Livingstone, ISBN: 044307593X 0443079838 (v. 1) 0443075247 (v. 2), (2000), 2228-2241.
Apicella, Michael A., et al., “Modification by sialic acid ofNeisseria gonorrhoeaelipooligosaccharide epitope expression in human urethral exudates: an immunoelectron microscopic analysis”,Journal of Infectious Diseases, 162(2), (Aug. 1990), 506-512.
Brozek, Kathryn A., et al., “Biosynthesis of Lipid A inEscherichia coli”, J. Biol. Chem., 265, (1990), 15410-15417.
Clementz, Tony, et al., “Function of theEscherichia colimsbB Gene, a Multicopy Suppressor of htrB Knockouts, in the Acylation of Lipid A”,The Journal of Biological Chemistry, 272, (1997), 10353-10360.
Harvey, H. A., et al., “Receptor-mediated endocytosis ofNeisseria gonorrhoeaeinto primary human urethral epithelial cells: the role of the asialoglycoprotein receptor”,Molecular Microbiology.42(3), (Nov. 2001), 659-672.
Jones, Bradley D., et al., “Study of the Role of the htrB Gene inSalmonella typhimuriumVirulence”,Infection and Immunity, 65 (11), (1997), 4778-4783.
Karow, Margaret L., et al., “Isolation and Characterization of theEscherichia coli htrBGene, Whose Product is Essential for Bacterial Viability Above 33 degrees C in Rich Media”,Journal of Bacteriology, 173, (1991), 741-750.
Kulshin, Vladimir A., et al., “Structural characterization of the lipid A component of pathogenicNeisseria meningitidis”, Journal of Bacteriology, 174(6), (Mar. 1992), 1793-1800.
Lee, Na-Gyong, et al., “Mutation of the htrB Locus ofHaemophilus influenzaeNontypable Strain 2019 Is Associated with Modifications of Lipid A and Phosphorylation of the Lipo-oligosaccharide”,J. Biol. Chem., 270, (1995), 27151-27159.
Nichols, W. A., et al., “htrB ofHaemophilus influenzae: Determination of Biochemical Activity and Effects on Virulence and Lipooligosaccharide Toxicity”,Journal of Endotoxin Research, 4, (1997), 163-172.
Post, Deborah M., et al., “Intracellular survival ofNeisseria gonorrhoeaein male urethral epithelial cells: importance of a hexaacyl lipid A”,Infection&Immunity.70(2), (Feb. 2002), 909-920.
Preston, Andrew, et al., “The Lipooligosaccharides of Pathogenic Gram-Negative Bacteria”,Critical Review in Microbiology, 22, (1996), 139-180.
Raetz, Christian R., et al., “Bacterial endotoxins: extraordinary lipids that activate eucaryotic signal transduction”,Journal of Bacteriology.175(18), (Sep. 1993), 5745-5753.
Raetz, Christian R., et al., “Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction”,FASEB Journal.5(12), (Sep. 1991), 2652-2660.
Richmond, Peter, et al., “Evaluation of De-O-Acetylated Meningococcal C Polysachharide-Tetanus Toxoid Conjugate Vaccine in Infancy: Reactogenicity, Immunogenicity, Immunologic Priming, and Bactericidal Activity against O-Acetylated and De-O-Acetylated Serogroup C Strains”,Infection and Immunity, 69 (4), (Apr. 2001), 2378-2382.
Schnaitman, Carl A., et al., “Genetics of lipopolysaccharide biosynthesis in enteric bacteria”,Microbiological Reviews.57(3), (Sep. 1993), 655-682.
Somerville, Jr., John E., et al., “A NovelEscherichia coliLipid A Mutant That Produces an Antiinflammatory Lipopolysaccharide”,J. Clin. Invest., 97, (1996), 359-365.
Steeghs, Liana, et al., “Meningitis bacterium is viable without endotoxin”,Nature.392(6675), (Apr. 1998), 449-50.
Steeghs, Liana, et al., “Outer membrane composition of a lipopolysaccharide-deficientNeisseria meningitidismutant”,EMBO Journal.20(24), (Dec. 2001), 6937-6945.
Sunshine, Melvin G., et al., “Mutation of the htrB Gene in a VirulentSalmonella typhimuriumStrain by Intergeneric Transduction: Strain Construction and Phenotypic Characterization”,Journal of Bacteriology, 179, (1997), 5521-5533.
Van Der Ley, Peter, et al., “Modification of lipid A biosynthesis inNeisseria meningitidisIpxL mutants: influence on lipopolysaccharide structure, toxicity, and adjuvant activity”,Infection&Immunity.69(10), (Oct. 2001), 5981-5990.
Vogel, Ulrich, “Mechanisms of Neisserial Serum Resistance”,Molecular Microbiology, 32, (1999), 1133-1139.
West, David, et al., “RecombinantNeisseria meningitidistransferrin binding protein A protects against experimental meningococcal infection”,Infection&Immunity.69(3), (Mar. 2001), 1561-1567,
Zhang, Q., et al., “Primary and booster mucosal immune responses to meningococcal group A and C conjugate and polysaccharide vaccines administered to university students in the United Kingdom”,Infection&Immunity.69(7), (Jul. 2001), 4337-4341.
Post, Deborah M., et al., “The msbB Mutant ofNeisseria meningitidisStrain NMB has a Defect in Lipooligosaccharide Assembly and Transport to the Outer Membrane”,Infection and Immunity, vol. 71, No. 2 (Feb. 2003), pp. 647-655.
Altschul et al., “Basic Local Alignment Search Tool,”J.Mol. Biol., 1990, 215:403-410.
Altschul et al., “Gapped BLAST and PSI-BLAST: a new generation of protein database search programs,”Nucl. Acids Res., 1997, 25(17):3389-3402.
Batzer et al., “Enhanced evolutionary PCR using oligonucleotides with inosine at the 3′-terminus,”Nucl. Acids Res., 1991, 19(18):5081.
Corpet et al., “Multiple sequence alignment with hierarchical clustering,”Nucl. Acids Res., 1988, 16(22):10881-10890.
Hanahan, “Studies on Transformation ofEscherichia coliwith Plasmids,”J. Mol. Biol., 1983, 166:557-580.
Harvey et al., “Immortalization of Human Urethral Epithelial Cells: a Model for the Study of the Pathogenesis of and the Inflammatory Cytokine Response toNeisseria gonorrhoeaeInfection,”Infect. Immun., 2002, 70(10):5808-5815.
Higgins and Sharp, “Fast and sensitive multiple sequence alignments on a microcomputer,”CABIOS, 1989, 5(2):151-153.
Higgins and Sharp, “CLUSTAL: a package for performing multiple sequence alignment on a microcomputer,”Gene, 1988, 73:237-244.
Huang et al., “Parallelization of a local similarity algorithm,”CABIOS, 1992, 8(2):155-165.
Karlin and Altschul, “Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes,”Proc. Natl. Acad. Sci. USA, 1990, 87:2264-2268.
Karlin and Altschul, “Applications and statistics for multiple high-scoring segments in molecular sequences,”Proc. Natl. Acad. Sci. USA, 1993, 90:5873-5877.
Lesse et al., “Increased resolution of lipopolysaccharides and lipooligosaccharides utilizing tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis,”J. Immunol. Meth., 1990, 126:109-117.
Mandrell et al., “Lipooligosaccharides (LOS) ofNeisseria gonorrhoeaeandNeisseria meningitidesHave Components That Are Immunochemically Similar to Precursors of Human Blood Group Antigens,”J. Exp. Med., 1988, 168:107-126.
McGhee et al.,

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