Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1993-09-17
1997-01-14
Kunz, Gary L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 53, 514 54, 536 171, 536 187, 536 52, 536 53, 536 553, 536117, A61K 3170, C07H 302, C07H 304
Patent
active
055939694
ABSTRACT:
A compound of the formula: ##STR1## wherein: each of R.sub.1, R.sub.1 ', R.sub.2 and R.sub.2 ' independent of each other is a substituted or unsubstituted, branched or linear C.sub.1-12 alkyl, alkene or alkyne group, R.sub.3 is OH, OCH.sub.3, CH.sub.2 COOH or ##STR2## wherein each of R.sub.2" and R.sub.2 '41 independent of each other is a substituted or unsubstituted, branched or linear C.sub.1-12 alkyl, alkene or alkyne group and:
REFERENCES:
patent: 3188309 (1965-06-01), Mukatyama et al.
patent: 4659567 (1987-04-01), Tramontano et al.
patent: 4792446 (1988-12-01), Kim et al.
patent: 4888281 (1989-12-01), Schochetman et al.
patent: 4912094 (1990-05-01), Myers et al.
patent: 4929604 (1990-05-01), Munford et al.
patent: 5066794 (1991-11-01), Saiba
patent: 5134230 (1992-07-01), Kusama et al.
Adorini, L. et al. (1988) Proc. Natl. Acad. Sci. USA 85, 5181-5185.
Alving, C. R., (1991) J. Immunol. Meth. 140, 1-13.
Alving, C. R. & Richards, R. L. (1990) J. Immunol. Lett. 25, 275-280.
Arata, S., Mashimo, J., Kasai, N., Okuda, K., Aihara, Y., Hasegawa, A., and Kiso, M., FEMS Microbiol lett 1987, 44, 231.
Arata, S., Mashimo, J., Kasai, N., Okuda, K., Aihara, Y., Kotani, S., Takada, H., Shiba, T., Kusumoto, S., Shimamoto, T., and Kusunose, N., FEMS Microbiol lett 1988, 49, 479.
Anderson, et al., CRU, 10 27 (1977).
Atherton, E. and Sheppard, R. J., J. Chem. Soc. Commun., 1151-1152 (1981).
Berzofsky, J. A. Science, 229, 932-940 (1985).
Blundell, J. et al., Nature, 304, 273-275 (1983).
Brade, L., Rietschel, E, Th., Kusumoto,. S., Shiba, T., and Brade, H., Infec Immunity 1986, 51, 110.
Brade, L., Bradenberg, K., Kuhn, H.-M., Kusumoto, S., Macher, I., Rietschel, E, T., and Brade, H., Infec. Immunity. 1987, 55, 2636.
Buchner, H. Berl Klin Wochenschr 1980, 47, 1084.
Carr, C. J. & Morrison, D. Rev. Inf. Dis. 6, 497-500 (1984).
Charon, D. and Szabo Carbohydrate Res. 1983, 111, C9. Ibid 1983, 111, C13-C15.
Clackson, T., Hoogenboom, H. R., Griffiths, A. D. & Winter, G. & Chiswell, D. J. Nature 352, 624-628, (1991).
Cohen, C. J., R. A. Janis, D. G. Taylor et al. In Calcium Antagonist and Cardiovascular Disease.
Coley, W. B, Inoperable sarcoma cured by mixed toxins of erysipelas and Bacillus prodigiosus. JAMA 1898, 31, 389-95 & 456-65.
Corvol, P. et al., J. Biol. Chem., 262(6), 2913-2918 (1987).
Erwin, L. A. and Munford, S. R., J. of Biol. Chem. 1990, 265, 16444.
Fersht, A. R., and A. J. Kirby. J. Am. Chem. Soc. 90:5833, 1968.
Fersht, A., Enzyme Structure and Mechanism, 2d ed., 433-436 (W. H. Freeman and Co., New York, 1985).
Finam, M,J., and Kishi, Y., Tetrahedron lett, 1982, 23, 2714.
Flick and Gifford (1984) J. Immun. Meth. 68, 167-75.
Frisch, B. et al. (1979) Eur. J. Immunol. 21, 185-193.
Galanos, C., Luderitz, O. & Westphal, O. Eur. J. Biochem. 24, 116-122 (1971).
Galanos, C., Reitschel, E. T, Luderittz, O, and Westphal, O, Intern Rev Biochem, Biochemistry of Lipids II, T. W. Goodwin(ed) University Park Press 1977, 14, 239.
Galanos, C., Reitschel, E. T., Luderittz, O., Westphal, O., Kim, Y. B, and Watson, D. W., Biological activities of lipid A complexed with BSA, Eur, J. Biochem. 1972, 31, 230.
Galanos, C., Luderitz, O., Freudenberg, M., Brade, L., Schade, U., Rietschel, E, Th., Kusumoto, S., and Shiba, T., Eur J Biochem1986, 160, 55.
Galanos, C., Luderitz, O., Rietschel, E, T., Westphal, O., Brade, H., Brade, L., Freudenberg, M., Schade, U., Imoto, M., Yoshimura, H., Kusumoto, S., and Shiba, T., Eur J Biochem 1985, 148, 1.
Galanos, C., Lehman, V., Luderitz, O., Rietschel, E, T., Westphal, O., Brade, H., Brade, L., Freudenberg, M, A., Hansen-Hagge, T., Luderitz, T., Mckenzie, G., Schade, U., Strittmater, W., Tanamoto, K., Zahringer, U., Imoto, M., Yoshimura, H., Yamamoto, M., Shimamoto, T., Kusumoto, S., and Shiba, T., Eur J Biochem 1984, 140, 221.
Geysen, H. M., et al., J. Immunological Methods, 102, 259-274 (1987).
Geysen, H. M., et al., Proc. Nat'l Acad. Sci. USA, 82, 178-182 (1985).
Geysen, H. M., et al., Science, 235, 1184 (1978).
Golenbock et al. (1991) J. Biol. Chem. 266, 19490-19498.
Greenman, R. L., Shein, R. M. H. G, Martin, M. A., Wenzel, R. P., Macintyre, N. R., Emmanuel, G., Chmel, H., Kohler, R. B., Arthy, M., Plouffe, J. & Russell, J. A., J. A. JAMA-J Am Med Assoc 266, 1097-1102 (1991).
Hagen, F. S. et al., "Expression and Characterization og Recombinant Human Acyloxyacyl Hydrolase, a Leukocyte Enzyme That Deacylates Bacterial Lipoplysaccharides" Biochemistry 30, (34), 8415-8423, (1991).
Hall, C. L. and Munford, R. S. Proc. Natl. Acad. Sci. 1983, 80, 6671.
Homma, J, Y., Matsuura, M., and Kumuzawa, Y., Drugs of the future 1989, 14, 645.
Homma, J, Y., Matsuura, M., Kanegasaki, S., Kawakubo, Y., Kojima, Y., Shibukawa, N., Kumazawa, Y., Yamamoto, A., Tanamoto, K., Yasuda, T., Imoto, M., Yoshimura, H., Kusumoto, S., and Shiba, T., J. Biochem. 1985, 98, 395.
Ho, D., J. Virol., 61, 2024 (1987).
Hopp, T. P. and Woods, K. R., Proc. Nat'l Acad. Sci. USA, 78, 3824-3828 (1981).
Huse, W., Sastry, L., Iverson, S., Kang, A., Altingmees, M. Burton, D., Benkovic, S. and Lerner, R Science 246, 1275-1281 (1989).
Ikeda, S., Nishimura, C., Nakatsuka, M., Homma, J, Y., Kiso, M., and Hasegawa., Antiviral Res 1988, 9, 37.
Ikeda, S., Kumazawa, Y., Nishimura, C., Nakatsuka, M., Homma, J, Y., Kiso, M., and Hasegawa, A., Int J Immunopharmacol 1988, 10, 331.
Ikeda, S., Kumuzawa, Y., Nishimura, C., Nakatsuka, M., Homma, J, Y., Kiso, M., and Hasagawa, A., Antiviral Res 1988, 10, 167.
Imoto, M., Yoshimura, H., Sekiguchi, N., Kusumoto, S., and Shiba, T., Tetrahedron lett 1985, 26, 1545.
Imoto, M., Kusumoto, S., Shiba, T., Rietschel, E, T., Galanos, C., and Luderitz, O., Tetrahedron Lett 1985, 26, 907.
Imoto, M., Kusumoto, S., Shiba, T., Naoki, H., Iwashita, T., Rietschel, E, T., Wollenweber, H, W., Galanos, C. and Luderitz, O. Tetrahydron Lett 1983, 24, 4017.
Imoto, M., Yoshimura, H., Kusumoto, S., Shiba, T., Proc Jpn Acad1984, 60B, 285.
Inage, M., Chaki, H., Imoto, M., Shimamoto, T., Kusumoto, S., and Shiba, T. Tetrahedron lett 1983, 24, 2011.
Inage, M., Chaki, H., Kusumoto, S., Shiba, T. Tetrahedron lett. 1981, 22, 2281.
Inage, M., Chaki, H., Kusumoto, S., and Shiba, T. Tetrahedron lett 1980, 21, 3889.
Inage, M., Chaki, H., Kusumoto, S., and Shiba, T., Chem. Lett 1982, 1281.
Inage, M., Chaki, H., Kusumoto, S., Shiba, T., Tai, A., Nakahata, M., Harada, T and Izumi, Y. Chem. Lett. 1980, 1373-6.
Jeannin et al. (1991) Gastroenterology 101, 726-733.
Jencks, W.P. Adv. Enzymol. 43:219, 1975.
Jacobs, et al., "Catalytic Antibodies", Journal of the American Chemical Society, v. 109, pp. 2174-2176, Apr. 1987.
Kanegasaki, S., Tanamoto, K., Yasuda, T., Homma, J, Y., Matsuura, M., Nakatsuka, M., Kumazawa, Y., Yamamoto. A., Shiba, T., Kusumoto, S., Imoto, M., Yoshimura, H., and Shimamoto, T., J Biochem 1986, 99, 1203.
Kanegasaki, S., Kojima, Y., Matsuura, M., Homma, J. Y., Yamamoto, A., Kumazawa, Y., Tanamoto, K., Tsumita, T., Imoto, M., Yoshimura, H., Yamamoto, M., Shimamoto, T., Kusumoto, S., and Shiba, T., Eur. J.Biochem 1984, 143, 237.
Kasai, N., Arata, S., Mashimo, J., Okuda, K., Aihara, Y., Kotani, S., Takada, H., Shiba, T., Kusumoto, S., Imoto, M., Yoshimura, H., and Shimamoto, T., Infec Immunity 1986, 51, 43.
Kasai, N., Arata, S., Mashimo, J., Okuda, K., Aihara, Y., Kotani, S., Takada, H., Shiba, T., and Kusumoto, S., Biochem. Biophys. Res. Commun 1985, 28, 607.
Katsuki, T., and Sharpless., J. Am. Chem. Soc, 1980, 102, 5974.
Katz D. M., et al., Biochemistry, 18, 690-697, (1979).
Ketchan, Jambotkar, and Martinelli., J. Org. Chem. 1962, 27, 4666.
Kiso, M., Tanaka, S., Fujita, M., Fujishima, Y., Ogawa, Y., Ishida, H., and Hasegawa, a., Carbohy. Res1987, 162, 127.
Kiso, M., Fujita, M., Hayashi, E., Hasegawa, A., J. Carbohy Chem 1987, 6, 691.
Kiso. M., Fujita, M., Tanahashi, M., Fujishima, Y., Ogawa, Y., and Hasegawa, A., Carbohy. Res1988, 177, 51.
Kiso, M., Ishida, H., and Hasegawa, A., Agri. Biol. Chem. 1984, 48, 251.
Kiso, M., and Hasegawa., Bacterial Endotoxin-Chemical, Biological And Clinical aspects, Homma, Y, J., Kanegasaki, O., Luderitz, O., Shiba, T., and Westphal (Eds), 1984, 39. (verlag Chemie).
Kiso, M., Tanaka
Darsley Michael J.
Kamireddy Balreddy
Massey Richard J.
Simpson David M.
Evans Barry
Fonda Kathleen Kahler
IGEN Incorporated
Kunz Gary L.
Salkeld Pamela G.
LandOfFree
Lipid-A analogs: monosaccharide and dissaccharide compounds for does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Lipid-A analogs: monosaccharide and dissaccharide compounds for , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lipid-A analogs: monosaccharide and dissaccharide compounds for will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1388212