Lipid A analog as stimulant for production of interleukin-1 in h

Details Lipid A analog as stimulant for production of interleukin-1 in h Lipid A analog as stimulant for production of interleukin-1 in h

1990-06-08

1992-10-27

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 42, 514 53, 536 173, 536 182, 536 187, 536 53, 536117, 536119, A61K 3170, A61K 31715

Patent

active

051589419

ABSTRACT:
This invention concerns the use of synthetic Lipid A analog P9132 to activate human monocytes, and inhibit growth of tumor cells.

REFERENCES:
patent: 4719202 (1988-01-01), van Boeckel et al.
patent: 4950645 (1990-08-01), Vosika et al.
Chemical Abstracts, vol. 109, No. 13, issued 1988, Sep. 26 (Columbus, Ohio, U.S.A.) Takahashi et al, "Structual Requirements of Endotoxic Lipopolysaccharides and Bacterial Cell Walls in Induction of Interleukin-1," see p. 38, col. 2, the abstract No. 104367k, Blood Purif. 1988 6(3), 188-206 (Eng).
Chemical Abstracts, vol. 109, No. 25, issued 1988, Dec. 19 (Columbus, Ohio, U.S.A.), Takada et al, "Structural Requirements of Lipid A Species in Activation of Clotting Enzymes from the Horseshoe Crab, and the Human Complement Cascade", see p. 623, col. 1, the abstract No. 228195x, Eur. J. Biochem. 1988, 175(3), 573-80 (Eng).
Chemical Abstracts, vol. 111, No. 15, issued 1989, Oct. 9 (Columbus, Ohio, U.S.A.) Hurme et al, "Comparison of Interleukin 1 Release and Interleukin 1, mRNA Expression of Human Monocytes Activated by Bacterial Lipopolysaccharide or Synthetic Lipid A", see p., col. 2, the abstract No. 132267n, Scand J. Immunol. 1989, 30(2), 259-63 (Eng).
T. Shimizu, et al., Chem. Pharm. Bull. 33 (10):4621-4624 (1985).
M. Kiso, et al., Carbohydrate Research 162:247-256 (1987).

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