Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active...
Reexamination Certificate
2005-04-05
2005-04-05
Jones, Dameron L. (Department: 1616)
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
C424S078010, C514S909000, C549S200000, C549S208000
Reexamination Certificate
active
06875428
ABSTRACT:
The invention features a method for treating obesity in a patient by administering to the patient a polymer that has been substituted with one or more groups that inhibit lipases, which are enzymes responsible for the hydrolysis of fat. The invention further relates to the polymers employed in the methods described herein as well as novel intermediates and methods for preparing the polymers.
REFERENCES:
patent: 3780171 (1973-12-01), Irmscher et al.
patent: 3923972 (1975-12-01), Fields et al.
patent: 4160826 (1979-07-01), Fischetti
patent: 4211765 (1980-07-01), Johnson et al.
patent: 4218443 (1980-08-01), Comai et al.
patent: 4265879 (1981-05-01), Fields et al.
patent: 4302450 (1981-11-01), Comai et al.
patent: 4432968 (1984-02-01), Page et al.
patent: 4959179 (1990-09-01), Aronson et al.
patent: 5063210 (1991-11-01), Lange, III et al.
patent: 5089163 (1992-02-01), Aronson et al.
patent: 5137716 (1992-08-01), Weisenfeld
patent: 5200183 (1993-04-01), Tang et al.
patent: 5286481 (1994-02-01), Weisenfeld
patent: 5308766 (1994-05-01), Dennis et al.
patent: 5376674 (1994-12-01), Derungs et al.
patent: 5401498 (1995-03-01), Kesseler et al.
patent: 5427777 (1995-06-01), St. Pierre et al.
patent: 5427919 (1995-06-01), Dennis et al.
patent: 5453282 (1995-09-01), Kanauchi et al.
patent: 5453429 (1995-09-01), Bliem et al.
patent: 5474993 (1995-12-01), Rubin et al.
patent: 5484777 (1996-01-01), Lange, III et al.
patent: 5567597 (1996-10-01), Dennis et al.
patent: 5569452 (1996-10-01), Amidon et al.
patent: 5597810 (1997-01-01), Hoffman et al.
patent: 5607669 (1997-03-01), Mandeville, III et al.
patent: 5618530 (1997-04-01), Mandeville, III et al.
patent: 5624963 (1997-04-01), Mandeville, III et al.
patent: 5629338 (1997-05-01), Okuda et al.
patent: 5665348 (1997-09-01), Okayama et al.
patent: 5674482 (1997-10-01), Regan et al.
patent: 5679717 (1997-10-01), Mandeville, III et al.
patent: 5693675 (1997-12-01), Mandeville, III et al.
patent: 5703188 (1997-12-01), Mandeville, III et al.
patent: 5750524 (1998-05-01), Mera et al.
patent: 6267952 (2001-07-01), Mandeville, III et al.
patent: 6352692 (2002-03-01), Mandeville, III et al.
patent: 0 050 347 (1982-04-01), None
patent: 0 381 262 (1990-08-01), None
patent: WO 9205788 (1992-04-01), None
Gargouri, Y., et al., “Ajoene prevents fat digestion by human gastric lipase in vitro,”Biochimica et Biophysica Acta. 1006:137-139 (1989).
Gargouri, Y., et al., “Covalent inhibition of digestive lipases: an in vitro study,”Biochimica et Biophysica Acta. 1344:6-37 (1997).
Karamac, M. and Amarowicz, R., “Inhibition of Pancreatic Lipase by Phenolic Acids, Examination in vitro,”Verlag der Zeitschrift für Naturforschung:903-905 (1996).
Marguet, F., et al., “Digestive lipases: inactivation by phosphonates,”Biochimica et Biophysica Acta. 1210:157-166 (1994).
Mannesse, M.L.M., et al., “Phosphonate analogues of Triacylglycerols are potent inhibitors of lipase,”Biochimica et Biophysica Acta. 1259:56-64 (1995).
Martichonok, V. and Jones, J.B., “(Z)-Heptadec-8-enylboronic acid: a potential lipase inhibitor,”J. Chem. Soc. Perkin Trans. I:2927-2929 (1995).
Vainio, P., et al., “Inhibition of Lipoprotein Lipase by Benzene Boronic Acid Effect of Apolipoprotein C-II,”Biochimica et Biophysica Acta. 711:386-390 (1982).
Bagree, A., et al., “Modification of ε- Amino Group of Lysine in Proteins by Acylation with Pyromellitic Dianhydride ando-Sulphobenzoic Anhydride,”FEBS Letters120(2):275-277 (1980).
Stadler, P., et al., “Inhibition of microbial lipases with stereoisomeric triradylglycerol analog phosphonates,”Biochimica et Biophysica Acta. 1304:229-244 (1996).
Kawaguchi, K., et al., “Hesperidin as an Inhibitor of Lipases from Procine Pancreas andPseudomonas,” Biosci. Biotech. Biochem.61(1):102-104 (1997).
Bochenek, W.J. and Rodgers, J.B., “Effect of Polyol Detergents on Cholesterol and Triglyceride Absorption,”Biochimica et Biophysica Acta489:503-506 (1977).
Comai, K. and Sullivan, A.C., “Antiobesity activity of pluronic L-101,”International Journal of Obesity4:33-42 (1980).
Han, L-K, et al., “Reduction in fat storage during chitin-chitosan treatment in mice fed a high-fat diet,”International Journal of Obesity23:174-179 (1999).
Moreau, Hervé, et al., “Inactivation of Gastric and Pancreatic Lipases by Diethylp-Nitrophenyl Phosphate,”Biochemistry30:1037-1041 (1991).
Kataoka K. and Miyazaki H., “Sensitive Glucose-Induced Change of the Lower Critical Solution Temperature of Poly[N,N-dimethylacrylamide-co-3-(acrylamido) phenyl-boronic Acid] in Physiological Saline,”Macromolecules, 27(4):1061-1062 (1994).
Wulff G. and Heinz-Günter P., “Influence of the Structure of the Binding Sites on the Selectivity for Racemic Resolution,”Makromol. Chem. 188:741-745 (1987).
De B., et al., “An Unequivocal Approach to Ascertain Asymmetric Induction in the Polymer Main Chain during Enantioselective Copolymerization of 1,2-Disubstituted Olefins,”Macromolecules,29(1):468-470 (1996).
Bisse E. and Wieland H., “Coupling ofm-aminophenylboronic Acid tos-triazine-activated Sephacryl: Use in the Affinity Chromatography of Glycated Hemoglobins,”Journal of Chromatography, 575:223-228 (1992).
Hisamitsu, I., et al., “Glucose-Responsive Gel From Phenylborate Polymer and Poly(Vinyl Alcohol): Prompt Response at Physiological pH Through the Interaction of borate with Amino Group in the Gel,”Pharmaceutical Research,14(3):289-293.
Wulff, G., “Selective Binding to Polymer Via Covalent Bonds. The Construction of Chiral Cavities as Specific Receptor Sites,”Pure&Appl. Chem.,54(11):2093-2102 (1982).
Shiino D., et al., “Amine Effect on Phyenylboronic Acid Complex with Glucose Under Physiological pH in Aqueous solution,”Biomater. Sci. Polymer, 2(8):697-705 (1996).
Miyazaki, H., et al., “Boronate-Containing Polymer as Novel Mitogen for Lymphocytes,”Biochemical and Biophysical Research Communications, 195(2):829-836 (1993).
Boie Molly Kate
Garigapati Venkata R.
Mandeville, III W. Harry
Genzyme Corporation
Jones Dameron L.
Ropes & Gray LLP
LandOfFree
Lipase inhibiting polymers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Lipase inhibiting polymers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lipase inhibiting polymers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3371703