Linking to chemical array assemblies with metal layers

Details Linking to chemical array assemblies with metal layers Linking to chemical array assemblies with metal layers

2006-10-31

2006-10-31

Goldberg, Jeanine A. (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S287200, C435S007100, C435S174000, C435S283100, C536S023100, C536S025300

Reexamination Certificate

active

07129046

ABSTRACT:
A method of producing a front surface modified substrate, which substrate includes a metal layer, and which is useful in the fabrication of an array of multiple probes bonded to a front surface of a substrate at different features of the array. The method includes providing the substrate wherein the front surface displays functional groups. The front surface is contacted with linker molecules each having a group which binds the linker molecule to the front surface following a reaction with a surface displayed functional group, which reaction does not produce a reagent which attacks the metal layer. To fabricate an array the front surface may be contacted with the probes or probe precursors to bind the probes or probe precursors to the front surface bound linker molecules.

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