Linking reagents for nucleotide probes

Details Linking reagents for nucleotide probes Linking reagents for nucleotide probes

1994-01-14

1996-12-17

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2534, 536 261, 536 262, 536 2622, 558 70, 558199, 558202, 562 8, 562 10, 562 23, C07H 102, C07H 1900, C07H 2100

Patent

active

055854818

ABSTRACT:
A versatile reagent with a non-nucleotide monomeric unit having a ligand, and first and second coupling groups which are linked to the non-nucleotide monomeric unit. The ligand can be either a chemical moiety, such as a label or intercalator, or a linking arm which can be linked to such a moiety. Such reagent permits preparation of versatile nucleotide
on-nucleotide polymers, having any desired sequence of nucleotide and non-nucleotide monomeric units, each of the latter of which bear a desired ligand. These polymers can for example, be used as probes which can exhibit enhanced sensitivity and/or which are capable of detecting a genus of nucleotides each species of which has a common target nucleotide sequence of interest bridged by different sequences not of interest.

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