Linking agents and methods

Details Linking agents and methods Linking agents and methods

1990-08-27

1993-06-08

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

536124, 540472, 540473, 546294, 548166, 5483071, C07D21372, C08B 3700

Patent

active

052181120

ABSTRACT:
Compounds containing carbohydrate moieties or carboxyl groups are linked to either compounds containing thiol moieties or electron-deficient moieties by the use of linking agents of the formula ##STR1## in which R.sup.1 is NH.sub.2 -- or NH.sub.2 --NH--; R.sup.2 is --NH--C(O)--, --C(O)--NH--, or --C(O)--; R.sup.3 is C.sub.1 -C.sub.10 alkylene, C.sub.5 -C.sub.7 cyclic alkylene, arylene, phenyl-substituted C.sub.1 -C.sub.10 alkylene, benzyl-substituted C.sub.1 -C.sub.10 alkylene, or amino-substituted C.sub.1 -C.sub.10 alkylene; R.sup.4 is H, acetyl, ##STR2## where R.sup.5 is C.sub.1 -C.sub.5 alkyl; m is zero or 1; and n ia zero or 1.

REFERENCES:
patent: 4508906 (1985-04-01), Bamberg et al.
patent: 4666503 (1987-05-01), Shiokawa et al.
patent: 4845108 (1989-07-01), Young et al.
patent: 4889866 (1989-12-01), Pfister et al.
patent: 4952235 (1990-08-01), Andree et al.
patent: 4970303 (1990-11-01), Reardan et al.
patent: 4975448 (1990-12-01), Schoenwald et al.

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