Linkers useful for the synthesis of conjugates of methyltrithio

Details Linkers useful for the synthesis of conjugates of methyltrithio Linkers useful for the synthesis of conjugates of methyltrithio

1995-06-05

1998-06-16

Achutamurthy, Ponnathapura

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 38, 560 19, 564152, 564163, 5303919, 530402, C07D20746, C07D20748, C07D29522

Patent

active

057672857

ABSTRACT:
This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

REFERENCES:
patent: 5053394 (1991-10-01), Ellestad et al.

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