Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-04-07
1999-01-05
Feisee, Lila
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 235, 536 2353, 536 242, 514 44, 4241351, 4241341, 4241921, 4241941, 435328, 4353201, 930310, 5303873, C12N 1511, C12N 1562, C12N 1513, C07H 2104
Patent
active
058564560
ABSTRACT:
The invention is directed to a novel peptide linker useful for connecting polypeptide constituents into a novel linked fusion polypeptide. The peptide linker of the invention provides greater stability and is less susceptible to aggregation than previously known peptide linkers. The peptide linker of the invention may be up to about 50 amino acids in length and contains at least one occurrence of a charged amino acid followed by a proline. When used for making a single chain Fv (sFv), the peptide linker is preferably from 18 to about 30 amino acids in length. A preferred embodiment of the peptide linker of the invention comprises the sequence:
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Filpula David R.
Whitlow Marc D.
Enzon Inc.
Feisee Lila
Lucas John
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