Linker for immobilization, modification and subsequent release o

Details Linker for immobilization, modification and subsequent release o Linker for immobilization, modification and subsequent release o

1996-02-01

1997-11-18

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2533, 536 2534, 435 91, 435 92, C07H 2100, C07H 2102, C07H 2104

Patent

active

056889402

ABSTRACT:
The invention is a method which allows the attachment of an alcohol to a substrate by the use of which chemical and/or enzymatic transformations of the alcohol are facilitated, and subsequently the modified alcohol can be released, if desired, under exquistely mild conditions, after selective removal of a protecting group from an expulsion promoting amino group.

REFERENCES:
patent: 5414077 (1995-05-01), Lin et al.
patent: 5539097 (1996-07-01), Arnold
S.L. Beaucage and R.P. Iyer, Advances in the Synthesis of oligonucleotides by the Phosphoramidite Approach, Tetrahedron, vol. 48, pp. 2223-2311, 1992.
H. Koster and K. Heyns, Polymer Support Oligonucleotide Synthesis. VII Use of Sephadex LH 20. Tetrahedron Letters, pp.1531, 1972.
G. R. Gough, M.J. Brunden and P.T. Gilham, 2'(3')-O-Benzyoyluridine 5' Linked to Glass: An All-purpose Support for Solid Phase Synthesis of Oligodeoxyribonucleotide, Tetrahedron Letters, vol. 24, pp. 5321-5324, 1983.
R. Crea and T. Horn, Synthesis of Oligonucleotides on Cellulose by a Phosphotriester Method, Nucleic Acids Researchh, vol. 8, pp. 2331-2348, 1980.
S. Scott, P. Hardy, R.C. Sheppard and M.J. McLean, A Universal Support for Oligonucleotide Synthesis, in "Innovations and Perspectives in Solid-Phase Synthesis", R. Epton, Ed., Mayflower Publishers, pp. 115-124, 1994.
P.S. Nelson, R.A Frye and E. Liu, Bifunctional Oligonucleotide Probes Synthesized Using a Novel CPG Support Are Able To Detect Single Base Pair Mutations, Nucleic Acids Research, vol. 17, pp. 7187-7194, 1989.
H. Vu, N. Joyce, M. Rieger, D. Walker, I. Goldknopf, T.S. Hill, K. Jayaraman and D. Mulvey, Use of Phthaloyl Protecting group for the Chem., vol. 6, pp. 599-607 (1995).
S.L. Beaucage and M.H. Caruthers, Deoxynucleoside Phosphoramidites--A New Class of Key Intermediates for Deoxypolynucleotide Synthesis, Tetrahedron Letters, vol. 22, pp. 1859-1862, 1982.
Y. Hayakawa, S. Wakabayashi, H. Kato and R. Noyori, The Allylic Protection Method in Solid-Phase Oligonucleotide Syntesis. An Efficient Preparation of Solid-Anchored DNA oligomers, J. Amer. Chem. Soc., vol. 112, pp. 1691-1696., 1990.
D. Hudson and M.H. Lyttle, Allyl Based Side-Chain Protection for SPPS, inPeptides, Chemsitry and Biology, Proceedings of the Twelfth American peptide Society, J. Rivier and J.A. Smth, Eds., pp. 583-584 (1992).
Ikehara et al., "The Synthesis of Polynucleotides," Advances in Carbohydrate Chemistry and Biochemistry, 36, 135-213 (1979); only pp. 135 and 207-213 supplied.

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